Optical coherence tomography in papilledema: A probe into the intracranial pressure correlation

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dc.contributor.authorBassi, Shikha Talwaren_US
dc.contributor.authorPamu, Rameshen_US
dc.contributor.authorAmbika, Selvakumaren_US
dc.contributor.authorPraveen, Smitaen_US
dc.contributor.authorPriyadarshini, Durgaen_US
dc.contributor.authorDharini, Vidhyaen_US
dc.contributor.authorPadmalakshmi, Ken_US
dc.date.accessioned2025-05-09T09:49:36Z
dc.date.available2025-05-09T09:49:36Z
dc.date.issued2024-05
dc.description.abstractPurpose: To study the optic nerve head characteristics on optical coherence tomography (OCT) in patients with papilledema and correlate them with intracranial pressure (ICP). Methods: A retrospective hospital?based study of 46 eyes of 23 patients with bilateral optic disc edema secondary to increased ICP. The clinical profile and the OCT features in terms of retinal nerve fiber layer thickness (RNFL), ganglion cell inner plexiform layer (GCIPL) thickness, and enhanced depth imaging (EDI) B scan images of the optic nerve head were studied and correlated with the ICP. Results: Papilledema was secondary to idiopathic intracranial hypertension (IIH) (n = 20), obstructive hydrocephalus (n = 2), and communicating hydrocephalus (n = 1). The mean ICP in 20 IIH patients was 347 mmH2O. The ICP and RNFL thickness in all four quadrants were found to be weakly positively correlated: superior RNFL r (38) = 0.17, P = 0.30, and nasal RNFL r (38) = 0.30, P = 0.05, inferior RNFL r (38) = 0.29, P = 0.07, and temporal RNFL, r (38) = ?0.001, P = 0.99. The GCIPL layer thickness and the ICP were weakly negatively correlated in all sectors: superior (38) = ?0.23, P = 0.16, superonasal, r (38) = ?0.07, P = 0.67, inferonasal r (38) = ?0.08, P = 0.64, inferior r (38) = ?0.21, P = 0.19, inferotemporal r (38) = ?0.23, P = 0.17, superotemporal, r (38) ?0.21, P = 0.20. Descriptive features on the B scan, such as peripapillary hyperreflective ovoid mass?like structures and microcystic spaces, were observed most commonly with an ICP of 251–350 mmH2O, and the hyperreflective dots in the RNFL layer and Bruch’s membrane inward denting were observed more commonly with an ICP of 351–450 mmH2O. Conclusion: The RNFL thickness in all four quadrants had a weak positive correlation, and the GCIPL layer had a weak negative correlation with the ICP. The EDI descriptive features on OCT may vary with ICP.en_US
dc.identifier.affiliationsDeputy Director, Department of Neuroophthalmology Services, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsResident, Department of Comprehensive Ophthalmology, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsDirector, Department of Neuroophthalmology Services, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsConsultant, Department of Neuroophthalmology Services, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsConsultant, Department of Neuroophthalmology Services, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsConsultant, Department of Neuroophthalmology Services, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsConsultant, Department of Neuroophthalmology Services, Sankara Nethralaya, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationBassi Shikha Talwar, Pamu Ramesh, Ambika Selvakumar, Praveen Smita, Priyadarshini Durga, Dharini Vidhya, Padmalakshmi K. Optical coherence tomography in papilledema: A probe into the intracranial pressure correlation. Indian Journal of Ophthalmology. 2024 May; 72(5): 672-676en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245191
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber5en_US
dc.relation.volume72en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_1648_23en_US
dc.subjectEnhanced depth imagingen_US
dc.subjectidiopathic intracranial hypertensionen_US
dc.subjectoptic nerve head drusenen_US
dc.subjectoptical coherence tomographyen_US
dc.titleOptical coherence tomography in papilledema: A probe into the intracranial pressure correlationen_US
dc.typeJournal Articleen_US
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