Cold spot assessment in Epithelial-Mesenchymal Transition: a histological predictor of tumor recurrence in oral cavity squamous cell carcinoma

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dc.contributor.authorRajashekar, Ken_US
dc.contributor.authorKhonglah, Yen_US
dc.contributor.authorRaphael, Ven_US
dc.contributor.authorShunyu, B.en_US
dc.date.accessioned2023-08-10T07:32:16Z
dc.date.available2023-08-10T07:32:16Z
dc.date.issued2022-06
dc.description.abstractObjectives: To investigate clinical implications of epithelial mesenchymal transition (EMT) expression in oral cavity squamous cell carcinoma (OSCC). Materials and Methods: E-cadherin and vimentin expression was studied in 50 newly diagnosed cases of OSCC who underwent surgical excision. EMT expression at non cold spot infiltrative margin and cold spot was studied and correlated with prognostic factors and disease-free survival (DFS). Results: EMT expression at the cold spot and non-cold spot infiltrative margin showed significant results with nodal status (P < 0.001, P < 0.009 respectively). On multivariate analysis, only EMT at the cold spot correlated significantly with prognostic factors (P < 0.030). The factors affecting DFS on Kaplan Meier index were EMT expression and differentiation (P < 0.002, P < 0.016 respectively) which proved significant in cox regression analysis. Conclusion: The study reveals that EMT expression at the cold spot is a significant biomarker for predicting lymph-node metastasis and tumor recurrence in OSCC.en_US
dc.identifier.affiliationsDepartment of Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Indiaen_US
dc.identifier.affiliationsDepartment of ENT, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Indiaen_US
dc.identifier.citationRajashekar K, Khonglah Y, Raphael V, Shunyu B.. Cold spot assessment in Epithelial-Mesenchymal Transition: a histological predictor of tumor recurrence in oral cavity squamous cell carcinoma. Indian Journal of Pathology & Microbiology. 2022 Jun; 65(2): 274-279en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223218
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume65en_US
dc.source.urihttps://doi.org/10.4103/IJPM.IJPM_875_20en_US
dc.subjectCold spot assessmenten_US
dc.subjectepithelial mesenchymal transitionen_US
dc.subjectoral cavity squamous cell carcinomaen_US
dc.titleCold spot assessment in Epithelial-Mesenchymal Transition: a histological predictor of tumor recurrence in oral cavity squamous cell carcinomaen_US
dc.typeJournal Articleen_US
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