Cardiovascular responses to phenylephrine and sodium nitroprusside during acute coronary occlusion in dogs.

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dc.contributor.authorHussain, M Een_US
dc.contributor.authorFahim, Men_US
dc.date.accessioned1994-10-01en_US
dc.date.accessioned2009-06-01T07:46:20Z
dc.date.available1994-10-01en_US
dc.date.available2009-06-01T07:46:20Z
dc.date.issued1994-10-01en_US
dc.description.abstractThe effects of administration of pressor agent phenylephrine (PE) and depressor agent, sodium nitroprusside (SNP) (10-40 micrograms/kg) on arterial blood pressure (ABP) and heart rate (HR) were investigated during acute occlusion of left anterior descending coronary artery (LAD) in anaesthetized, artificially ventilated dogs with and without the influence of selective blockade of autonomic nervous system (ANS). ABP response to PE was significantly (P < 0.05) attenuated following 4 hrs of LAD occlusion in all the four groups of animals. SNP response at higher dose (40 micrograms/kg) was also significantly (P < 0.05) attenuated 4 hrs after LAD occlusion in ANS intact, beta-blocked and atropinized groups. The bradycardia response to PE after LAD occlusion was abolished in vagotomized group while in the other three groups, it was significantly attenuated following 4 hrs of LAD occlusion. The tachycardia response to SNP was significantly (P < 0.05) attenuated 4 hrs after LAD occlusion in ANS intact and atropinized animals. The response was abolished in beta-blocked animals and no significant change occurred (P > 0.05) in vagotomized group. This study suggests that the cardiovascular reflex effects of PE and SNP are significantly attenuated following acute LAD occlusion. Blocking any of the components of ANS changed this responsiveness.en_US
dc.description.affiliationDepartment of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi.en_US
dc.identifier.citationHussain ME, Fahim M. Cardiovascular responses to phenylephrine and sodium nitroprusside during acute coronary occlusion in dogs. Indian Journal of Physiology and Pharmacology. 1994 Oct; 38(4): 252-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108410
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdrenergic beta-Antagonists --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshCoronary Circulation --drug effectsen_US
dc.subject.meshCoronary Disease --drug therapyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Rate --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshNitroprusside --pharmacologyen_US
dc.subject.meshPhenylephrine --pharmacologyen_US
dc.subject.meshVagotomyen_US
dc.titleCardiovascular responses to phenylephrine and sodium nitroprusside during acute coronary occlusion in dogs.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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