Comparative evaluation of optical coherence tomography in glaucomatous, ocular hypertensive and normal eyes.

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dc.contributor.authorSubbiah, Sujataen_US
dc.contributor.authorSankarnarayanan, Sen_US
dc.contributor.authorThomas, Philip Aen_US
dc.contributor.authorNelson Jesudasan, C Aen_US
dc.date.accessioned2007-07-28en_US
dc.date.accessioned2009-05-29T09:43:33Z
dc.date.available2007-07-28en_US
dc.date.available2009-05-29T09:43:33Z
dc.date.issued2007-07-28en_US
dc.description.abstractBACKGROUND: To correlate the findings of optical coherence tomography (OCT) evaluation of retinal nerve fiber layer (RNFL) thickness with visual field changes in glaucomatous, ocular hypertensive and normal eyes. MATERIALS AND METHODS: Thirty consecutive normal, 30 consecutive ocular hypertensive and 30 consecutive glaucomatous eyes underwent a complete ophthalmic examination, including applanation tonometry, disc evaluation, (30-2) Humphrey field analyzer white on white (W/W) perimetry and short- wavelength automated perimetry. Thickness of the RNFL around the optic disc was determined with 3.4 mm diameter-wide OCT scans. Average and segmental RNFL thickness values were compared among all groups. A correlation was sought between global indices of perimetry and RNFL thickness. RESULTS: Of the 90 eyes enrolled (mean age of patients 52.32+/-10.11 years), the mean RNFL thickness was significantly less in ocular hypertensive (82.87+/-17.21 mm; P =0.008 and glaucomatous eyes (52.95+/-31.10 microm; P < 0.001), than in normals (94.26+/-12.36 microm). The RNFL was significantly thinner inferiorly in glaucomatous eyes (64.41+/-43.68 microm; P<0.001). than in normals (120.15+/-14.32 microm) and ocular hypertensives (107.87+/-25.79 microm; P<0.001). Ocular hypertensives had thinner RNFL in the nasal, inferior and temporal quadrants (P<0.001) when compared to normals. Global indices in ocular hypertensives on SWAP showed Mean Deviation (MD) of 5.32+/-4.49, Pattern Standard Deviation (PSD) 3.83+/-1.59 and Corrected Pattern Standard Deviation (CPSD) 2.84+/-1.85. The RNFL thickness could not be significantly correlated with global indices of visual fields in ocular hypertensives. CONCLUSION: Optical coherence tomography is capable of detecting changes at the level of RNFL in ocular hypertensive eyes with normal appearance of discs and W/W perimetry fields.en_US
dc.description.affiliationInstitute of Ophthalmology, Joseph Eye Hospital, Tiruchirappalli, Tamil Nadu, India. umasujata@yahoo.comen_US
dc.identifier.citationSubbiah S, Sankarnarayanan S, Thomas PA, Nelson Jesudasan CA. Comparative evaluation of optical coherence tomography in glaucomatous, ocular hypertensive and normal eyes. Indian Journal of Ophthalmology. 2007 Jul-Aug; 55(4): 283-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/71908
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGlaucoma, Open-Angle --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshIntraocular Pressureen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOcular Hypertension --diagnosisen_US
dc.subject.meshOptic Disk --pathologyen_US
dc.subject.meshReproducibility of Resultsen_US
dc.subject.meshRetinal Ganglion Cells --pathologyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTomography, Optical Coherence --methodsen_US
dc.titleComparative evaluation of optical coherence tomography in glaucomatous, ocular hypertensive and normal eyes.en_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
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