Versatile Use of Mycobacterium indicus pranii (MIP) Vaccine

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dc.contributor.authorThangaraju, Pen_US
dc.contributor.authorSajitha, Ven_US
dc.contributor.authorSree, Sudha, TYen_US
dc.contributor.authorSudheer, Den_US
dc.contributor.authorPamidimarri, VNen_US
dc.contributor.authorBalasubramanian, Ven_US
dc.contributor.authorBabu, Sen_US
dc.date.accessioned2023-08-09T06:22:36Z
dc.date.available2023-08-09T06:22:36Z
dc.date.issued2023-03
dc.description.abstractMycobacterium indicus pranii (MIP) earlier known as Mw is a soil-borne, non-pathogenic, saprophytic and rapidly growing strain of mycobacteria. MIP is approved as a vaccine/ immunomodulator for various indications including mycobacterium infections like leprosy in humans. Its administration has resulted in satisfactory clinical improvement, accelerated bacillary clearance, and increased immune responses to Mycobacterium leprae antigens, thereby shortening the full recovery time of the patients. It also shares its antigens with M.tuberculosis. In the last decade, RCTs have been done establishing immunotherapeutic properties of MIP in the treatment of leprosy, tuberculosis, warts and experimently in leishmaniasis. Through its immune inducing and cytotoxic property, it has also proved beneficial for human use especially in treating lung cancer. The beneficial role of it is also being explored in breast, cervical, oral, liver, and bladder cancers. Various studies on MIP have shown that it has immune-modulating properties in humans. The curiosity of the human mind has led to it being tried in Covid treatment trials. The results have shown that administering MIP has lowered inflammatory markers in Covid 19 patients, promising us for it to be a potential treatment option. More RCTs with a larger sample size should be done to establish this. Cytokine storm seen in bacterial sepsis is also decreased with MIP administration. Considering the encouraging results in hastening recovery in various diseases it appears that MIP is perhaps not being exploited to its fullest potentialen_US
dc.identifier.affiliationsAssistant Professor, Department of Pharmacology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.en_US
dc.identifier.affiliationsSenior Resident, Department of Microbiology, All India Institute of Medical sciences, Raipur, Chhattisgarh, India.en_US
dc.identifier.affiliationsAssistant Professor, Department of Pharmacology, All India Institute of Medical Sciences, Deogarh , Jharkhand, India.en_US
dc.identifier.affiliationsDepartment of Industrial Biotechnology, Gujarat Biotechnology University, GD Rd, Sector 11, Gandhinagar, Gujarat 382010, India.en_US
dc.identifier.affiliationsDepartment of Industrial Biotechnology, Gujarat Biotechnology University, GD Rd, Sector 11, Gandhinagar, Gujarat 382010, India.en_US
dc.identifier.affiliationsPhD, Amity Institute of Biotechnology, Amity University Chhattisgarh, Raipur 493225, Chhattisgarh, India.en_US
dc.identifier.affiliationsAssistant Professor, Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, Indiaen_US
dc.identifier.citationThangaraju P, Sajitha V, Sree Sudha TY, Sudheer D, Pamidimarri VN, Balasubramanian V, Babu S. Versatile Use of Mycobacterium indicus pranii (MIP) Vaccine. Indian Journal of Leprosy. 2023 Mar; 95: 51-64en_US
dc.identifier.issn0254-9395
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222640
dc.languageenen_US
dc.publisherHind Kusht Nivaran Sangh (Indian Leprosy Association)en_US
dc.relation.volume95en_US
dc.source.urihttps://www.ijl.org.in/article-detail/95/446en_US
dc.subjectMycobacterium indicus praniien_US
dc.subjectMIPen_US
dc.subjectMycobacterium wen_US
dc.subjectMwen_US
dc.subjectImmunotherapyen_US
dc.subjectCovid 19en_US
dc.subjectLeprosyen_US
dc.subjectTuberculosisen_US
dc.subjectImmunomodulatoren_US
dc.titleVersatile Use of Mycobacterium indicus pranii (MIP) Vaccineen_US
dc.typeJournal Articleen_US
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