Neuropharmacological actions of some newly synthesized Mannich bases.

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Date
1981-07-01
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Abstract
Benzamido (alkyl) methyl pyrrolidine Mannich bases were synthetized and subjected to certain neuropharmacological studies. All the bases reduced the pentobarbitone sleeping time and rota-rod grip of rats. The Mannich bases II, III and V raised the minimal electro-shock seizure threshold of rats. The TAB-induced pyrexia was not reduced by the bases I and III in rabbits. None of the bases showed any significant analgesic activity.
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Tongia SK, Trivedi CP, Matkar SV, Chouhan RS, Kaushal R. Neuropharmacological actions of some newly synthesized Mannich bases. Indian Journal of Physiology and Pharmacology. 1981 Jul-Sep; 25(3): 269-73
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https://imsear.searo.who.int/handle/123456789/106206
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Indian Journal of Physiology and Pharmacology