Light & electron microscopy of proliferating oval cells during early chemical hepatocarcinogenesis.

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dc.contributor.authorGera, Nen_US
dc.contributor.authorBhatia, Aen_US
dc.contributor.authorSood, S Ken_US
dc.date.accessioned1991-06-01en_US
dc.date.accessioned2009-05-27T06:43:36Z
dc.date.available1991-06-01en_US
dc.date.available2009-05-27T06:43:36Z
dc.date.issued1991-06-01en_US
dc.description.abstractEarly hepatic changes were studied in male albino rats (70) of Sprague Dawley strain fed a choline devoid diet containing 0.05 per cent w/w AAF (2-acetylaminofluorene) for 12 days. Proliferating periductal and ductal cells appeared in the portal area on days 1 and 3 respectively in the experimental group. On day 7, these cells infiltrated within the sinusoids of adjacent lobules up to the first one or two layers of hepatocytes. Subsequently, these cells extended up to the midzonal region on day 21 and by day 24 the entire lobule was infiltrated. Formation of duct like structures by the proliferating cells was seen on day 21. Ultrastructurally both periductal and ductal cells showed only a few organelles. Periductal and ductal cells are the earliest cells to appear in the portal area in chemically induced hepatocarcinogenesis. Its undifferentiated ultrastructure, may suggest the stem cell nature of these cells.en_US
dc.description.affiliationDepartment of Pathology, University College of Medical Sciences, Delhi.en_US
dc.identifier.citationGera N, Bhatia A, Sood SK. Light & electron microscopy of proliferating oval cells during early chemical hepatocarcinogenesis. Indian Journal of Medical Research. 1991 Jun; 94(): 200-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/17630
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.mesh2-Acetylaminofluoreneen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshCholine Deficiencyen_US
dc.subject.meshLiver --pathologyen_US
dc.subject.meshLiver Neoplasms, Experimental --chemically induceden_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshTime Factorsen_US
dc.titleLight & electron microscopy of proliferating oval cells during early chemical hepatocarcinogenesis.en_US
dc.typeJournal Articleen_US
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