‘Obesageing’: Linking obesity & ageing

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dc.contributor.authorGhosh, Sen_US
dc.contributor.authorSinha, JKen_US
dc.contributor.authorRaghunath, Men_US
dc.date.accessioned2020-04-10T01:42:39Z
dc.date.available2020-04-10T01:42:39Z
dc.date.issued2019-05
dc.description.abstractObesity is one of the leading causes of preventable mortalities in many parts of the globe. The rise in geriatric population due to better treatment opportunities has also emerged as a major public health challenge. Both of these health challenges have impacted developed as well as developing countries. Obesity is attributed as a powerful risk factor of a variety of health problems such as cardiovascular diseases, hypertension, type 2 diabetes, dementia, neuropsychiatric diseases and many more. On the other hand, ageing is a natural process involving a gradual decline in physiological functions and is associated with similar co-morbidities as obesity. This review discusses about the commonalities (termed as ‘Obesageing') between the pathological phenomenon of obesity and normal physiological process of ageing. A unique rodent model of obesageing has been developed (WNIN/Ob) that has characteristics of morbid obesity as well as premature ageing. Such a novel animal model would facilitate the understanding of the complex interplay of different mechanisms that are common to obesity and ageing and help to devise strategies in future to tackle the growing burden of obesity and ageing.en_US
dc.identifier.affiliationsEndocrinology and Metabolism Division, ICMR-National Institute of Nutrition, Hyderabad, Indiaen_US
dc.identifier.affiliationsEndocrinology and Metabolism Division, ICMR-National Institute of Nutrition, Hyderabad; Amity Institute of Neuropsychology & Neurosciences, Amity University, Noida, Indiaen_US
dc.identifier.citationGhosh S, Sinha JK, Raghunath M. ‘Obesageing’: Linking obesity & ageing. Indian Journal of Medical Research. 2019 May; 149(5): 610-615en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195894
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber5en_US
dc.relation.volume149en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_2120_18en_US
dc.subjectAccelerated ageingen_US
dc.subjectcognitive declineen_US
dc.subjectdementiaen_US
dc.subjectinflammationen_US
dc.subjectnicotinamide adenine dinucleotideen_US
dc.subjectoxidative stressen_US
dc.subjectWistar of National Institute of Nutrition obese raten_US
dc.title‘Obesageing’: Linking obesity & ageingen_US
dc.typeJournal Articleen_US
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