Quantitation of proteinuria in nephrotic syndrome by spot urine protein creatinine ratio estimation in children.
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2009-01-03
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Abstract
In Nephrotic Syndrome the amount of protein excretion is a reflection of activity of disease. Quantitative measurement of proteinuria by a 24-hour urine collection has been the accepted method of evaluation. Recent studies have shown that calculation of protein/creatinine ratio in a spot urine sample correlates well with the 24-hour urine protein (24-HUP) excretion. A study was conducted to compare the accuracy of a spot urinary protein/creatinine ratio (P/C ratio) and urinary dipstick with the 24-hour urine protein. Fifty two samples from 26 patients of nephrotic syndrome were collected. This included a 24-hour urine sample followed by the next voided random spot sample. The protein/creatinine ratio was calculated and dipstick was performed on the spot sample. This was compared with the 24-hour urine protein excretion. The correlation between the three samples was statistically highly significant (p<0.001) for all levels of proteinuria. The normal value of protein/creatinine ratio in Indian children was also estimated on 50 normal children admitted in the ward without any renal diseases calculated to be 0.053 (SE of mean +/-0.003).
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Mymensingh Medical Journal.
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Biswas A, Kumar R, Chaterjee A, Ghosh JK, Basu K. Quantitation of proteinuria in nephrotic syndrome by spot urine protein creatinine ratio estimation in children. Mymensingh Medical Journal. 2009 Jan; 18(1): 67-71