Effect of centchroman on cellular and humoral immunity.

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dc.contributor.authorThomas, Lictoen_US
dc.contributor.authorAsad, Mohammaden_US
dc.contributor.authorHrishikeshavan, Heremaglur Jagannathen_US
dc.contributor.authorChandrakala, Gowda Kallenahallien_US
dc.date.accessioned2007-10-15en_US
dc.date.accessioned2009-06-01T06:10:49Z
dc.date.available2007-10-15en_US
dc.date.available2009-06-01T06:10:49Z
dc.date.issued2007-10-15en_US
dc.description.abstractCentchroman (Ormeloxifene) is a nonsteroidal selective estrogen receptor modulator that is used as once a week oral contraceptive agent. The effect of centchroman on the immune system was evaluated by using different experimental models such as carbon clearance test, cyclophosphamide induced neutropenia, neutrophil adhesion test, effect on serum immunoglobulins, mice lethality test and indirect haemagglutination test. The first three models namely carbon clearance test, cyclophosphamide induced neutropenia and neutrophil adhesion test were used to study cell mediated immunity while the latter three models were used to see the effect on humoral immunity. Centchroman was administered orally at a dose of 5 mg/kg and levamisole (2.5 mg/kg/ p.o) was used as standard drug. Centchroman significantly increased the levels of serum immunoglobulins and also prevented the mortality induced by bovine Pasteurella multocida in mice. It also increased significantly the circulating antibody litre in indirect haemagglunation test. However, it did not show any significant effect on phagocytic index in carbon clearance assay and nor did influence the adhesion of neutrophils in the neutrophil adhesion test. Centchroman was also not effective in preventing the cyclophosphamde induced neutropenia. Hence, it was concluded that centchroman increases humoral immunity with no significant effect on cell mediated immunity.en_US
dc.description.affiliationKrupanidhi College of Pharmacy, #5, Sarjapur Road, Koramangala, Bangalore.en_US
dc.identifier.citationThomas L, Asad M, Hrishikeshavan HJ, Chandrakala GK. Effect of centchroman on cellular and humoral immunity. Indian Journal of Physiology and Pharmacology. 2007 Oct-Dec; 51(4): 387-94en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107186
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibody Formation --drug effectsen_US
dc.subject.meshCell Adhesionen_US
dc.subject.meshCentchroman --pharmacologyen_US
dc.subject.meshContraceptives, Postcoital, Synthetic --pharmacologyen_US
dc.subject.meshCyclophosphamide --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemagglutination Testsen_US
dc.subject.meshImmunity, Cellular --drug effectsen_US
dc.subject.meshImmunoglobulins --blooden_US
dc.subject.meshMiceen_US
dc.subject.meshNeutrophils --drug effectsen_US
dc.subject.meshPhagocytosis --drug effectsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSelective Estrogen Receptor Modulators --pharmacologyen_US
dc.titleEffect of centchroman on cellular and humoral immunity.en_US
dc.typeJournal Articleen_US
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