Efficacy of octreotide in the control of acute upper gastrointestinal bleeding.

Simple item page
dc.contributor.authorKullavanuaya, Pen_US
dc.contributor.authorManotaya, Sen_US
dc.contributor.authorThong-Ngam, Den_US
dc.contributor.authorMahachai, Ven_US
dc.contributor.authorKladchareon, Nen_US
dc.date.accessioned2009-05-27T21:57:43Z
dc.date.available2009-05-27T21:57:43Z
dc.date.issued2001-12-10en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractTo evaluate the efficacy and safety of octreotide in the control of acute upper gastrointestinal (GI) bleeding and prevention of rebleeding, the Gastroenterology Unit, Chulalongkorn University Hospital, conducted a prospective open study in patients with acute upper GI bleeding. All patients with acute upper GI bleeding were given octreotide by intravenous infusion. The patients then had endoscopic confirmation within 24 hours, were divided into variceal and nonvariceal groups, and then randomly allocated to receive either 48 hours of octreotide infusion or 48 hours of octreotide infusion plus 72 hours subcutaneous injection. Efficacy and safety of octreotide were evaluated during the 5 days observation period. Forty-three patients with acute upper GI bleeding were treated with octreotide infusion. After endoscopy, 16 patients in the variceal group and 22 patients in the non-variceal group were randomized to receive 48 hours infusion or 48 hours infusion plus 72 hours subcutaneous infusion. Failure to control active bleeding occurred in 11 patients (28.9%) and failure to prevent rebleeding was found in 5 patients (13.2%). The results showed that the effect of octreotide infusion in controlling acute upper GI bleeding appeared to be not different between the variceal and non-variceal causes. Subcutaneous injection of octreotide for another 72 hours showed no apparent benefit for the prevention of rebleeding.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine, Chulalongkom University, Bangkok, Thailand.en_US
dc.identifier.citationKullavanuaya P, Manotaya S, Thong-Ngam D, Mahachai V, Kladchareon N. Efficacy of octreotide in the control of acute upper gastrointestinal bleeding. Journal of the Medical Association of Thailand. 2001 Dec; 84(12): 1714-20en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45706
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Hemorrhage --drug therapyen_US
dc.subject.meshHemostatics --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOctreotide --therapeutic useen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRecurrence --prevention & controlen_US
dc.titleEfficacy of octreotide in the control of acute upper gastrointestinal bleeding.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Medical Association of Thailand