Presence of diarrhea associated with better outcomes in patients with COVID-19 – A prospective evaluation

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dc.contributor.authorSingh, Seeraten_US
dc.contributor.authorSamanta, Jayantaen_US
dc.contributor.authorSuri, Vikasen_US
dc.contributor.authorBhalla, Ashishen_US
dc.contributor.authorPuri, Goverdhan Dutten_US
dc.contributor.authorSehgal, Rakeshen_US
dc.contributor.authorKochhar, Rakeshen_US
dc.date.accessioned2023-08-09T06:46:30Z
dc.date.available2023-08-09T06:46:30Z
dc.date.issued2022-09
dc.description.abstractPurpose: Gastrointestinal (GI) manifestations have been well documented in patients with coronavirus disease 2019 (COVID-19), but its clinical impact on the course of the disease is debatable. Majority of the available data is retrospective, and hence this prospective study was planned to study the impact of GI symptoms on COVID-19 outcome. Methods: All COVID-19 patients admitted in a tertiary care centre from August–October 2020 were screened and patients without pre-existing GI diseases were included. A detailed history of the various symptoms including duration was documented. Various baseline laboratory investigations and inflammatory markers were conducted as per the protocol. Patients with and without diarrhea were compared for the various disease outcome parameters. Results: Of the 244 patients screened, 203 patients (128 males; 63.1%) were included. Respiratory symptoms alone were present in 49 (24.1%), GI symptoms alone in 20 (9.9%) and 117 (57.6%) had both. Overall GI symptoms was noted in 137 (67.5%) cases with the commonest being diarrhea (61; 30.0%). Patients with both respiratory and any GI symptoms showed a lower trend towards need for mechanical ventilation (12.2% vs 7.7%; p ¼ 0.35) and mortality (10.2% vs 4.3%; p ¼ 0.14) compared to respiratory symptoms alone, although not statistically significant. Patients with diarrhea (n ¼ 61) had no mortality (0% vs 7.7%; p ¼ 0.036) or need for mechanical ventilation and shorter hospital stay compared to those who did not have diarrhea. Conclusion: GI symptoms are frequent in patients with SARS-CoV-2 infection and the commonest is diarrhea. Diarrhea is a harbinger of better outcome with lower mortality among COVID-19 positive patients.en_US
dc.identifier.affiliationsDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Anesthesia, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Virology, Post Graduate Institute of Medical Education and Research, Chandigarh, Indiaen_US
dc.identifier.citationSingh Seerat, Samanta Jayanta, Suri Vikas, Bhalla Ashish, Puri Goverdhan Dutt, Sehgal Rakesh, Kochhar Rakesh. Presence of diarrhea associated with better outcomes in patients with COVID-19 – A prospective evaluation. Indian Journal of Medical Microbiology. 2022 Sept; 40(3): 404-408en_US
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222839
dc.languageenen_US
dc.publisherIndian Association of Medical Microbiologistsen_US
dc.relation.issuenumber3en_US
dc.relation.volume40en_US
dc.source.urihttps://doi.org/10.1016/j.ijmmb.2022.04.002en_US
dc.subjectCoronavirusen_US
dc.subjectDiarrheaen_US
dc.subjectGastrointestinalen_US
dc.subjectFecalen_US
dc.subjectSARS-CoV-2en_US
dc.titlePresence of diarrhea associated with better outcomes in patients with COVID-19 – A prospective evaluationen_US
dc.typeJournal Articleen_US
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