A double blind randomized control trial, comparing effect of drospirenone and gestodene to sexual desire and libido.

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dc.contributor.authorOranratanaphan, Shinaen_US
dc.contributor.authorTaneepanichskul, Surasaken_US
dc.date.accessioned2009-05-27T20:48:11Z
dc.date.available2009-05-27T20:48:11Z
dc.date.issued2006-10-30en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractBACKGROUND: Oral contraceptive is the most commonly used method of fertility control. Yasmin is a combination of a novel progestogen with anti-androgenic and anti-mineralcorticoid activities (3 mg Drospirenone (DRSP) and 30 microg ethinylestradiol (EE)). It has been shown in many clinical trials that Yasmin is an efficacious oral contraceptive, lacking undesired effects as with other oral contraceptives such as weight gain. However the effects of Yasmin on sexual desire and libido have not been intensively investigated so far OBJECTIVE: Investigate the effects of Yasmin on sexual desire, libido and changes in the free androgen index (FAI) compare to Meliane (75 microg gestodene + 20 microg ethinylestradiol). MATERIAL AND METHOD: The authors' report the results of a double blind randomized controlled study using a translated version of the Female Sexual Function Index questionnaire (FSFI) for the assessment of the sexual function. The free androgen index was calculated from measurements of testosterone and sexual hormone binding globulin. RESULT: The result shows statistically significant improvements regarding sexual desire, arousal and overall satisfaction in the Yasmin group. Additionally, an increased frequency of orgasms in the Meliane group was reported. Statistically significant differences between the two treatments regarding changes in the FSFI score and changes in the free androgen index have not been observed. CONCLUSION: The novel oral contraceptive containing drospirenone (Yasmin) and the non-anti-androgenic progestin containing oral contraceptive (Meliane) do not show unfavorable effects on sexual response and libido.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Rama IV Rd, Bangkok 10330, Thailand.en_US
dc.identifier.citationOranratanaphan S, Taneepanichskul S. A double blind randomized control trial, comparing effect of drospirenone and gestodene to sexual desire and libido. Journal of the Medical Association of Thailand. 2006 Oct; 89 Suppl 4(): S17-22en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/43662
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshAndrogensen_US
dc.subject.meshAndrostenes --pharmacologyen_US
dc.subject.meshContraceptives, Oral, Synthetic --pharmacologyen_US
dc.subject.meshEthinyl Estradiol --pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHealth Surveysen_US
dc.subject.meshHumansen_US
dc.subject.meshNorpregnenes --pharmacologyen_US
dc.subject.meshPatient Satisfactionen_US
dc.subject.meshProgesterone Congeners --pharmacologyen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshSexual Behavior --drug effectsen_US
dc.subject.meshThailanden_US
dc.subject.meshTime Factorsen_US
dc.titleA double blind randomized control trial, comparing effect of drospirenone and gestodene to sexual desire and libido.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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