CD8+ Mycosis Fungoides in Peripheral Blood; A Rare Finding

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dc.contributor.authorMeraj, Fatimaen_US
dc.contributor.authorKhan, Hamzaen_US
dc.contributor.authorZaman, Amna Qamar uzen_US
dc.contributor.authorJama, Sabaen_US
dc.date.accessioned2023-08-25T07:35:57Z
dc.date.available2023-08-25T07:35:57Z
dc.date.issued2022-10
dc.description.abstractCutaneous T cell lymphomas are mature lymphomas of T lymphocyte presenting with skin lesions and/or systemic manifestations. Majority of these cases show CD4+ phenotype and are classified as Mycosis Fungoides (MF)/Sezary syndrome (SS) spectrum.Here we present a case of 74-year-old male patient, having no known comorbid, presented in Dr. Ziauddin Hospital, Karachi OPD with complains of generalized skin lesions, itching for 2 years, generalized weakness for 4 months and no lymphadenopathy or visceromegaly. CBC showed absolute lymphocytosis and absolute eosinophilia. Some lymphocytes exhibited cerebriform nuclei. CT scan neck, chest and abdomen showed bilateral enlarged superficial inguinal lymph nodes and multiple enlarged bilateral axillary lymph nodes. Skin biopsy was inconclusive. Immunophenotyping of peripheral blood was then performed which showed an aberrant T cell population showing positivity for CD3, CD8, CD2, CD25 and negative for CD4, CD45, CD5, CD30, CD56 with variable expression of CD7. Case was finalized as CD8+ Mycosis Fungoides with peripheral blood involvement.These findings are very rare and highlight the importance of integrated approach to clinical course, morphological findings and other ancillary tests to be used in correlation with each other. These findings also highlight the diversity present in T cell malignancies in terms of immunophenotype.en_US
dc.identifier.affiliationsHematology Department, Indus Hospital and Health Network, Karachi, Pakistan.bHaematology Department, Dr.Ziauddin Hospital, Clifton Campus, Karachi, Pakistan.en_US
dc.identifier.citationMeraj Fatima, Khan Hamza, Zaman Amna Qamar uz, Jama Saba. CD8+ Mycosis Fungoides in Peripheral Blood; A Rare Finding. International Blood Research & Reviews. 2022 Jan; 13(4): 124-129en_US
dc.identifier.issn2321–7219
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/225669
dc.languageenen_US
dc.publisherSciencedomain Internationalen_US
dc.relation.issuenumber4en_US
dc.relation.volume13en_US
dc.source.urihttps://dx.doi.org/10.9734/IBRR/2022/v13i4291en_US
dc.subjectImmunophenotypeen_US
dc.subjectlymphadenopathyen_US
dc.subjectlymphomasen_US
dc.subjectMycosis Fungoides.en_US
dc.titleCD8+ Mycosis Fungoides in Peripheral Blood; A Rare Findingen_US
dc.typeJournal Articleen_US
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