Diagnostic Challenges in Hematological Malignancies in Nigeria and their Impact on Treatment Outcome

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dc.contributor.authorObu, Sylvia Ifeomaen_US
dc.contributor.authorDibigbo–Ibeaji, Ndudien_US
dc.contributor.authorObu, Gabriel Obisikeen_US
dc.contributor.authorIlikannu, Samuel Okwuchukwuen_US
dc.date.accessioned2025-05-09T06:23:06Z
dc.date.available2025-05-09T06:23:06Z
dc.date.issued2024-12
dc.description.abstractHaematological malignancy constitutes a major public health disease burden globally due to the degree of mortality and morbidity they cause. Aim: This review was aimed at exploring and reporting some of the difficulties that hinder early/accurate diagnosis and management of haematological malignancies in Nigeria emphasizing a single centre experience and to further highlight how they affect treatment outcome. Methodology: Google scholar, Pubmed and African Journals online sites were explored in July 2024. Relevant articles were selected. The most senior consultant haematologist in the single centre in South South Nigeria being studied was interviewed and account was documented. Results: The difficulties encountered in the prompt/proper diagnosis and management of haematological malignancies reported by the studies and the clinician interviewed include, visiting orthopaedic and other specialists as well as herbalists and spiritualists for several months before reporting to the haematology clinic, mis – and/or missed diagnosis due to inadequate diagnostic equipment and techniques like use of morphological studies alone for Rowmanawsky stained blood picture examination and histological diagnosis without cytogenetics, immunophenotyping, polymerase chain reaction fluorescent insitu hybridization, poverty, cultural and religious beliefs. Poor treatment outcome as a result of these challenges were also reported. Conclusion: Enlightenment campaigns on the benefits of early diagnosis and prompt presentation to the hospital should be encouraged. Provision of up-to-date advanced technologies for early/accurate diagnosis and sub classification of haematologiacl malignancies should be made in main health facilities across the country. Diagnosis and treatment of haematological malignancies should be built into the National Health Insurance scheme to strengthen the system in this regard.en_US
dc.identifier.affiliationsMolecular/Research Laboratory, Centre for Disease Control and Research, Federal Medical Centre, Asaba, Delta State, Nigeriaen_US
dc.identifier.affiliationsHaematology Department, Federal Medical Centre, Asaba, Delta State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Orthopedic and Trauma, Federal Medical Center, Asaba, Delta State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynaecology Federal Medical Center, Asaba, Delta State, Nigeria.en_US
dc.identifier.citationObu Sylvia Ifeoma, Dibigbo–Ibeaji Ndudi, Obu Gabriel Obisike, Ilikannu Samuel Okwuchukwu. Diagnostic Challenges in Hematological Malignancies in Nigeria and their Impact on Treatment Outcome . International Blood Research & Reviews. 2024 Oct; 15(4): 8-15en_US
dc.identifier.issn2321-7219
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242675
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber4en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.9734/ibrr/2024/v15i4345en_US
dc.subjectDifficultiesen_US
dc.subjecttreatment outcomeen_US
dc.subjectdiagnosisen_US
dc.subjecthaematological malignanciesen_US
dc.subjectleukaemiaen_US
dc.subjectlymphomaen_US
dc.titleDiagnostic Challenges in Hematological Malignancies in Nigeria and their Impact on Treatment Outcomeen_US
dc.typeJournal Articleen_US
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