Ophthalmology practice in COVID-19 pandemic: Performance of rapid antigen test versus real time-reverse transcription polymerase chain reaction in a tertiary eye care institute in South India

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dc.contributor.authorSarkar, Sandipen_US
dc.contributor.authorDeb, Amit Kumaren_US
dc.contributor.authorSingh, Rakeshen_US
dc.contributor.authorDhodapakar, Rahulen_US
dc.contributor.authorGokhale, Tanmayen_US
dc.contributor.authorKaliaperumal, Subashinen_US
dc.date.accessioned2023-08-25T06:33:00Z
dc.date.available2023-08-25T06:33:00Z
dc.date.issued2022-05
dc.description.abstractPurpose: To assess the rapid antigen test (RAT) against the gold standard reverse transcription?polymerase chain reaction (RT?PCR) to screen COVID?19 infection in asymptomatic patients undergoing ophthalmic procedures. Methods: This was a retrospective hospital?based study. Point?of?care (PoC) RAT was performed using nasopharyngeal swab, while RT?PCR for SARS?CoV?2 viral RNA was performed using both nasopharyngeal and throat swabs. Results: A total of 629 patients were tested for SARS?CoV?2 by using both RAT and RT?PCR. Only one patient had tested positive for SARS?CoV?2 with both RAT and RT?PCR, while two patients had tested positive with RT?PCR after an initial negative RAT. The positivity rate for RAT was 0.15% (1/629), and that for RT?PCR was 0.47%. Percent agreement or proportion of agreement observed between the two tests was 99.68%, while Cohen’s kappa coefficient value was 0.49. The sensitivity of RAT in comparison to RT?PCR was 33.33%, specificity was 100%, positive predictive value was 100%, and negative predictive value was 99.68%. Conclusion: The sensitivity and Cohen’s kappa coefficient in our study were low but that can be attributed to the overall low positivity rates with both RAT and RT?PCR. However, percent agreement observed between the two tests was very high. Therefore, we recommend initial screening of all the patients for COVID?19 symptoms followed by RAT before performing any ophthalmic surgical procedure to ensure the safety of the health care professionals as well as the patients.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.citationSarkar Sandip, Deb Amit Kumar, Singh Rakesh, Dhodapakar Rahul, Gokhale Tanmay, Kaliaperumal Subashin. Ophthalmology practice in COVID-19 pandemic: Performance of rapid antigen test versus real time-reverse transcription polymerase chain reaction in a tertiary eye care institute in South India. Indian Journal of Ophthalmology. 2022 May; 70(5): 1761-1765en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224317
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber5en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_21_22en_US
dc.subjectCOVID?19en_US
dc.subjectophthalmic surgeryen_US
dc.subjectrapid antigen testen_US
dc.subjectRT?PCRen_US
dc.titleOphthalmology practice in COVID-19 pandemic: Performance of rapid antigen test versus real time-reverse transcription polymerase chain reaction in a tertiary eye care institute in South Indiaen_US
dc.typeJournal Articleen_US
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