Influence of drug susceptibility on treatment outcome and susceptibility profile of failures to category II regimen.

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dc.contributor.authorJoseph, Pauline
dc.contributor.authorChandrasekaran, V
dc.contributor.authorThomas, A
dc.contributor.authorGopi, P G
dc.contributor.authorRajeswari, R
dc.contributor.authorBalasubramanian, R
dc.contributor.authorSubramani, R
dc.contributor.authorSelvakumar, N
dc.contributor.authorSantha, T
dc.date.accessioned2013-05-24T09:22:54Z
dc.date.available2013-05-24T09:22:54Z
dc.date.issued2006-07
dc.description.abstractObjective: To assess the influence of drug resistance on treatment outcome among patients treated with Category-II regimen and document drug susceptibility pattern of “Failures” to this regimen. Design: A retrospective analysis of patients registered from May 1999 through December 2004. Results: Treatment success was 42% among 572 patients and was similar among patients with fully susceptible or resistant but non-MDR organisms (41% of 254 and 40% of 128 patients, respectively). Among 49 MDR-TB patients, 27% had successful treatment outcome. The failure rates among patients with fully susceptible, resistant but non-MDR and MDR bacilli, were 6%, 12% and 27% respectively. Default was significantly higher among males (53% vs. 34%: p<0.01) smokers (57% vs. 36%: p <0.001), alcoholics (58% vs. 39%: p <0.001) and patients with higher initial smear grading (2+ or 3+, 56% vs. scanty or 1+, 44%: p <0.01). DST results were available for 60% (31 of 52) of failures and 10 had MDR-TB. Conclusion: The low success rate to the re-treatment regimen was mainly due to non-compliance. Failure was observed among 9% of patients and MDR-TB was 32% among Category II failures. The currently recommended Category II regimen appears to be adequate for majority of re-treatment cases.en_US
dc.identifier.citationJoseph Pauline, Chandrasekaran V, Thomas A, Gopi P G, Rajeswari R, Balasubramanian R, Subramani R, Selvakumar N, Santha T. Influence of drug susceptibility on treatment outcome and susceptibility profile of failures to category II regimen. Indian Journal of Tuberculosis. 2006 Jul; 53(3): 141-148.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/146923
dc.language.isoenen_US
dc.source.urihttps://medind.nic.in/ibr/t06/i3/ibrt06i3p141.pdfen_US
dc.subjectTreatment outcomeen_US
dc.subjectCategory II regimenen_US
dc.subjectfailureen_US
dc.subjectRNTCPen_US
dc.subjectMDR-TBen_US
dc.titleInfluence of drug susceptibility on treatment outcome and susceptibility profile of failures to category II regimen.en_US
dc.typeArticleen_US
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