Mutational Pathways in Colorectal Carcinoma Cell Lines.
| dc.contributor.author | Bhattacharyya, N P | |
| dc.contributor.author | Meuth, M | |
| dc.date.accessioned | 2015-07-15T05:11:31Z | |
| dc.date.available | 2015-07-15T05:11:31Z | |
| dc.date.issued | 1995-04 | |
| dc.description.abstract | We studied the nature of mutational events in two highly malignant human colorectal carcinoma cell lines. In HCT116, the frequency of micro-satellite instability as detected by the electrophoretic shifts in the allele sizes of micro-satellite DNA sequence was 22% and 80% in two loci (D16S303 and D16S295) of dinucleotide repeats. In SW620, we failed to detect such mutation at any of the two micro satellite loci studied. However, there was a high frequency loss of heterozygosity in the micro satellite locus D16S303. Such high frequency loss of the D16S303 allele extended to other linked loci covering about 9 mega base pairs (Mbp). This set of data indicates that at least two pathway are involved in the development of colon tumour. | en_US |
| dc.identifier.citation | Bhattacharyya N P, Meuth M. Mutational Pathways in Colorectal Carcinoma Cell Lines. Indian Journal of Human Genetics. 1995 Apr; 1(2): 87-92. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/159767 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.ijhg.com/article.asp?issn=0971-6866;year=1995;volume=1;issue=2;spage=87;epage=92;aulast=Bhattacharyya;type=2 | en_US |
| dc.subject | Colorectal carcinoma | en_US |
| dc.subject | mutations | en_US |
| dc.subject | microsetellite markers | en_US |
| dc.title | Mutational Pathways in Colorectal Carcinoma Cell Lines. | en_US |
| dc.type | Article | en_US |