Preliminary report: a comparative clinical trial of artemether and quinine in severe falciparum malaria.

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dc.contributor.authorKarbwang, Jen_US
dc.contributor.authorSukontason, Ken_US
dc.contributor.authorRimchala, Wen_US
dc.contributor.authorNamsiripongpun, Wen_US
dc.contributor.authorTin, Ten_US
dc.contributor.authorAuprayoon, Pen_US
dc.contributor.authorTumsupapong, Sen_US
dc.contributor.authorBunnag, Den_US
dc.contributor.authorHarinasuta, Ten_US
dc.date.accessioned2009-05-27T14:38:26Z
dc.date.available2009-05-27T14:38:26Z
dc.date.issued1992-12-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractTwenty-six patients with severe falciparum malaria were randomized to be treated with quinine or artemether. Twelve patients received quinine at the standard dose and fourteen patients received artemether intramuscularly at a total dose of 640 mg over 7 days. The patients were kept in the hospital for at least 7 days. Peripheral smear was performed 6-hourly until there was no parasitemia, then daily until discharged. Adverse effects were monitored through physical examination, laboratory findings and questionnaires. Laboratory examination was performed on admission, day 2, day 4 weekly until discharged. The patients in both groups were comparable in age, body weight, admission parasitemia, hemoglobin and white blood cell count. The survival rates were 93% and 58% in artemether and quinine groups, respectively (p = 0.052 at 95% confidence, using Fisher's exact test). The parasite and fever clearance times, and the time taken to gain consciousness in cerebral malaria patients were not significantly different between the two groups. Adverse effects in the quinine group consisted of dizziness and vertigo which were found in 4 patients. No adverse effects were noticed in the artemether group. This preliminary report suggests that artemether is a good alternative drug for severe falciparum malaria and seems to be better than quinine regarding survival rate and side effects. Confirmation of these findings in a larger study size is needed.en_US
dc.description.affiliationFaculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationKarbwang J, Sukontason K, Rimchala W, Namsiripongpun W, Tin T, Auprayoon P, Tumsupapong S, Bunnag D, Harinasuta T. Preliminary report: a comparative clinical trial of artemether and quinine in severe falciparum malaria. The Southeast Asian Journal of Tropical Medicine and Public Health. 1992 Dec; 23(4): 768-72en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30678
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAntimalarials --therapeutic useen_US
dc.subject.meshArtemisininsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Failure, Acute --parasitologyen_US
dc.subject.meshMalaria, Falciparum --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshQuinine --therapeutic useen_US
dc.subject.meshSesquiterpenes --therapeutic useen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshTreatment Outcomeen_US
dc.titlePreliminary report: a comparative clinical trial of artemether and quinine in severe falciparum malaria.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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