Screening Parameters for COPD-OSA Overlap Syndrome in COPD Patients: Indian Perspective

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dc.contributor.authorDeshmukh, Ien_US
dc.contributor.authorGothi, Den_US
dc.contributor.authorVaidya, Sen_US
dc.contributor.authorPatro, M.en_US
dc.date.accessioned2023-08-09T06:08:43Z
dc.date.available2023-08-09T06:08:43Z
dc.date.issued2023-03
dc.description.abstractIntroduction: As Indian patients have different predisposing morphological characteristics, we undertook this study to evaluate the clinical profile of overlap syndrome and compare them with COPD patients to find out the screening tools for obstructive sleep apnea (OSA) in Indian chronic obstructive pulmonary disease (COPD) patients. Aims and objectives: • To study the clinical profile of patients with overlap syndrome. • To compare them with COPD patients. • To develop screening tools for overlap syndrome in COPD. Materials and methods: A prospective case-control study was carried out in a tertiary care center. Overnight pulse oximetry was carried out for all COPD patients. Those having snoring or saw-tooth pattern on overnight oximetry were subjected to level 1 polysomnography. About 30 patients of overlap syndrome were compared with 65 COPD patients. Results: The mean age in overlap syndrome group (56.9 ± 6.86 years) was significantly lower (p < 0.01). The daytime PaO2 and lowest nocturnal saturation were significantly lower in overlap group. PaCO2 and forced expiratory volume at 1 second (FEV1) were significantly higher. For diagnosing overlap syndrome, the positive and the negative predictive values of snoring were 84.42 and 100%; of body mass index (BMI) ?25 kg/m2 were 86.67 and 98.88%; and of excessive daytime sleepiness were 37.57 and 97.86%, respectively. Conclusion: Absence of snoring and BMI <25 kg/m2 virtually rules out overlap syndrome. The EDS has a high false-positive rate for predicting OSA. Patients having overlap syndrome have poor daytime and nocturnal oxygenation despite good lung functions.en_US
dc.identifier.affiliationsDepartment of Pulmonary Medicine, ESI PGIMSR, New Delhi, Indiaen_US
dc.identifier.citationDeshmukh I, Gothi D, Vaidya S, Patro M.. Screening Parameters for COPD-OSA Overlap Syndrome in COPD Patients: Indian Perspective. Indian Journal of Chest Diseases & Allied Sciences. 2023 Mar; 65(1): 6-11en_US
dc.identifier.issn0377-9343
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221855
dc.languageenen_US
dc.publisherJaypee Brothers Medical Publishers Pvt. Ltden_US
dc.relation.issuenumber1en_US
dc.relation.volume65en_US
dc.source.urihttps://doi.org/10.5005/jp-journals-11007-0058en_US
dc.subjectBody mass indexen_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectForced expiratory volume at 1 seconden_US
dc.subjectObstructive sleep apneaen_US
dc.subjectSnoringen_US
dc.titleScreening Parameters for COPD-OSA Overlap Syndrome in COPD Patients: Indian Perspectiveen_US
dc.typeJournal Articleen_US
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