Evaluation of lactate dehydrogenase, creatine kinase and hepatic enzymes for the retrospective diagnosis of perinatal asphyxia among sick neonates.

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dc.contributor.authorReddy, Sanathen_US
dc.contributor.authorDutta, Sourabhen_US
dc.contributor.authorNarang, Anilen_US
dc.date.accessioned2008-02-04en_US
dc.date.accessioned2009-05-27T05:08:27Z
dc.date.available2008-02-04en_US
dc.date.available2009-05-27T05:08:27Z
dc.date.issued2008-02-04en_US
dc.description.abstractIt is difficult to make a retrospective diagnosis of perinatal asphyxia in symptomatic neonates delivered non-institutionally. We studied serum creatine kinase muscle-brain fraction (CK-MB), lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (SGOT) and glutamic pyruvate transaminase (SGPT) for differentiating asphyxiated (n=25) from non-asphyxiated (n=20) neonates who present with non-specific signs of sickness. CK-MB was assayed at 8 and 24 h; and LDH, SGOT and SGPT at 72 h of life. On comparing cases and controls, median 8-hr CK-MB [80 U/L vs. 26 U/L respectively, P< 0.001], median 24-hr CK-MB [33.5 U/L vs. 21.5 U/L respectively, P=0.009] and median LDH [965 U/L vs. 168 U/L respectively, P< 0.001] were higher in asphyxiated neonates. Raised LDH had 100% sensitivity, while CK-MB had 100% specificity for asphyxia. LDH had the highest area under ROC curve (0.998). We conclude that LDH at 72 hr of life is most accurate at differentiating asphyxiated from non-asphyxiated symptomatic neonates.en_US
dc.description.affiliationNewborn Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012, India.en_US
dc.identifier.citationReddy S, Dutta S, Narang A. Evaluation of lactate dehydrogenase, creatine kinase and hepatic enzymes for the retrospective diagnosis of perinatal asphyxia among sick neonates. Indian Pediatrics. 2008 Feb; 45(2): 144-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/8534
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshAlanine Transaminase --blooden_US
dc.subject.meshAspartate Aminotransferases --blooden_US
dc.subject.meshAsphyxia Neonatorum --blooden_US
dc.subject.meshCreatine Kinase --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshL-Lactate Dehydrogenase --blooden_US
dc.subject.meshPredictive Value of Testsen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSensitivity and Specificityen_US
dc.titleEvaluation of lactate dehydrogenase, creatine kinase and hepatic enzymes for the retrospective diagnosis of perinatal asphyxia among sick neonates.en_US
dc.typeJournal Articleen_US
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