Paucity of anti-hepatitis C virus antibodies in the serum of Indian patients with Sjogren's syndrome and inflammatory myositis.

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dc.contributor.authorWanchu, Aen_US
dc.contributor.authorChawla, Yen_US
dc.contributor.authorDhiman, R Ken_US
dc.contributor.authorSud, Aen_US
dc.contributor.authorBambery, Pen_US
dc.date.accessioned2003-04-17en_US
dc.date.accessioned2009-05-29T12:35:39Z
dc.date.available2003-04-17en_US
dc.date.available2009-05-29T12:35:39Z
dc.date.issued2003-04-17en_US
dc.description.abstractSeveral extrahepatic manifestations have been associated with infection with Hepatitis C virus (HCV) infection. It has been associated with Sjogren's syndrome (SS) and inflammatory myositis (IM). The objective was to look at the prevalence of anti-HCV antibodies in the serum of SS and IM patients of Indian origin. Individuals satisfying the European Economic Community criteria for the diagnosis of SS and those satisfying the criteria of Bohan and Peter for the diagnosis of IM were recruited in the study. Routine evaluation for liver functions was made. Anti-HCV antibodies were tested by a third generation ELISA, using microplate HCV3.0 ELISA. Of the 23 patients with SS studied, 14 had extraglandular features. The commonest were anaemia and arthritis in six each, followed by in lymphopenia in two. One patient each had interstitial lung disease, hypothyroidism and chronic active hepatitis. Twenty-two patients with IM were studied alongside. None of the patients had abnormal liver functions. One patient with primary SS tested positive for anti-HCV antibodies. None of the patients with inflammatory myositis tested positive for anti-HCV antibodies. The presence of anti-HCV antibodies in our cohort of patients with SS and IM is low and more in keeping with the generally low prevalence of the infection in the Indian population.en_US
dc.description.affiliationDepartment of Internal Medicine, Post-Graduate Institute of Medical Education and Research, Chandigarh. awanchu@yahoo.comen_US
dc.identifier.citationWanchu A, Chawla Y, Dhiman RK, Sud A, Bambery P. Paucity of anti-hepatitis C virus antibodies in the serum of Indian patients with Sjogren's syndrome and inflammatory myositis. Indian Journal of Pathology & Microbiology. 2003 Apr; 46(2): 191-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74756
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis C --complicationsen_US
dc.subject.meshHepatitis C Antibodies --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyositis --etiologyen_US
dc.subject.meshSjogren's Syndrome --etiologyen_US
dc.titlePaucity of anti-hepatitis C virus antibodies in the serum of Indian patients with Sjogren's syndrome and inflammatory myositis.en_US
dc.typeJournal Articleen_US
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