Development of anti-idiotypic antibodies to HLA antigens during pregnancy.

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dc.contributor.authorAgrawal, Sen_US
dc.contributor.authorSharma, R Ken_US
dc.contributor.authorKishore, Ren_US
dc.contributor.authorAgarwal, S Sen_US
dc.date.accessioned1994-01-01en_US
dc.date.accessioned2009-05-27T07:49:00Z
dc.date.available1994-01-01en_US
dc.date.available2009-05-27T07:49:00Z
dc.date.issued1994-01-01en_US
dc.description.abstractThirty one pregnant women whose sera were initially positive for anti HLA antibodies were retested for lymphocytotoxicity 7-9 months after delivery. In the second testing 10 women were found to have lost the cytotoxic antibodies. These sera were tested for presence of anti-idiotypic antibodies by complement dependent cytotoxicity (CDC). In all ten sera tested, CDC blocking antibody was detected by inhibition technique at different dilutions. These antibodies directed specifically against the HLA antigen of the spouse. This CDC blocking factor could be the anti-idiotypic antibody (Ab2) directed against the cytotoxic anti-HLA antibody (Ab1). In one woman who conceived a second time, repeat sample obtained at the 7th month of the second pregnancy showed reappearance of the specific anti-HLA antibody. This may suggest that the Ab1-Ab2 network is under dynamic regulation.en_US
dc.description.affiliationDepartment of Medical Genetics, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow.en_US
dc.identifier.citationAgrawal S, Sharma RK, Kishore R, Agarwal SS. Development of anti-idiotypic antibodies to HLA antigens during pregnancy. Indian Journal of Medical Research. 1994 Jan; 99(): 42-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/22180
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAntibodies, Anti-Idiotypic --immunologyen_US
dc.subject.meshAntibody Formationen_US
dc.subject.meshCytotoxicity Tests, Immunologicen_US
dc.subject.meshFemaleen_US
dc.subject.meshHLA Antigens --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin Idiotypes --immunologyen_US
dc.subject.meshPregnancy --immunologyen_US
dc.titleDevelopment of anti-idiotypic antibodies to HLA antigens during pregnancy.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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