Changes in vitamin C and vitamin E during oxidative stress in myocardial reperfusion.

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dc.contributor.authorSood, Reemaen_US
dc.contributor.authorNarang, A P Sen_US
dc.contributor.authorAbraham, Rebeccaen_US
dc.contributor.authorArora, Umaen_US
dc.contributor.authorCalton, Rajneeshen_US
dc.contributor.authorSood, Nitinen_US
dc.date.accessioned2007-04-08en_US
dc.date.accessioned2009-06-01T05:44:50Z
dc.date.available2007-04-08en_US
dc.date.available2009-06-01T05:44:50Z
dc.date.issued2007-04-08en_US
dc.description.abstractInjury to the myocardial tissue due to ischemia and reperfusion occurs because of imbalance between the formation of oxidants and available antioxidants in the heart. Levels of vitamin C (ascorbic acid) and vitamin E (alpha--tocopherol) were evaluated in 52 patients of acute myocardial infarction (AMI) treated by streptokinase. They were further divided into reperfused group (39 patients) and non-reperfused group (13 patients). Twenty normal healthy subjects served as controls. Vitamin C and vitamin E were estimated in study group before and after thrombolytic therapy and in controls. Vitamin C levels were low in AMI cases as compared to controls (8.74 +/- 1.87 and 10.63 +/- 3.26 mg/L, respectively, P < 0.001). Trend of fall in vitamin C levels in the two study groups was not statistically significant. Vitamin E levels declined from 12.19 +/- 6.71 to 9.96 +/- 6.50 mg/L by 4 hours which was significant (P < 0.01) in the reperfused group, but the change in non-reperfused group (9.28 +/- 6.37 to 9.35 +/- 6.07 mg/dL by 4 hours) was non-significant. This is because of increased consumption of this antioxidant in suppressing the oxidative stress which occurs with reperfusion. Vitamin E can be proposed as a valid marker for reperfusion.en_US
dc.description.affiliationDepartment of Biochemistry, Dayanand Medical College & Hospital, Ludhiana.en_US
dc.identifier.citationSood R, Narang AP, Abraham R, Arora U, Calton R, Sood N. Changes in vitamin C and vitamin E during oxidative stress in myocardial reperfusion. Indian Journal of Physiology and Pharmacology. 2007 Apr-Jun; 51(2): 165-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106851
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAscorbic Acid --blooden_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshMyocardial Infarction --blooden_US
dc.subject.meshMyocardial Reperfusion Injury --blooden_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshStreptokinase --therapeutic useen_US
dc.subject.meshVitamin E --blooden_US
dc.titleChanges in vitamin C and vitamin E during oxidative stress in myocardial reperfusion.en_US
dc.typeJournal Articleen_US
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