Penicillamine induced pseudoxanthoma elasticum with elastosis perforans serpiginosa.

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dc.contributor.authorRath, Namitaen_US
dc.contributor.authorBhardwaj, Amiten_US
dc.contributor.authorKar, Hemant Kumaren_US
dc.contributor.authorSharma, P Ken_US
dc.contributor.authorBharadwaj, Meenakhshien_US
dc.contributor.authorBharija, S Cen_US
dc.date.accessioned2009-05-28T08:48:49Z
dc.date.available2009-05-28T08:48:49Z
dc.date.issued2005-05-06en_US
dc.description.abstractLong term D-penicillamine therapy, especially when used to treat Wilson's disease has been shown to cause elastosis perforans serpiginosa, pseudoxanthoma elasticum perforans and other degenerative dermatoses. We report a 23-year-old male patient who presented with multiple firm papules, nodules over the neck, axillae, front of elbows for five years. He was a known case of Wilson's disease on long-term treatment with penicillamine for the past 12 years. The papulonodular lesions were non-tender and some were discrete while others were arranged in a circinate pattern. There was central scarring of the skin within the circinate lesions. In addition, there were several small yellowish papules on both sides of the neck which eventually became confluent to form plaques. Histopathology confirmed the diagnosis of elastosis perforans serpiginosa and pseudoxanthoma elasticum. He was treated with cryotherapy (using liquid nitrogen through cryojet) for former lesions. The lesions showed remarkable improvement after five sittings. Now the patient is under trientine hydrochloride (750 mg twice daily) for Wilson's disease.en_US
dc.description.affiliationDepartment of Dermatology, Dr. RML Hospital, New Delhi, India.en_US
dc.identifier.citationRath N, Bhardwaj A, Kar HK, Sharma PK, Bharadwaj M, Bharija SC. Penicillamine induced pseudoxanthoma elasticum with elastosis perforans serpiginosa. Indian Journal of Dermatology, Venereology and Leprology. 2005 May-Jun; 71(3): 182-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/53161
dc.language.isoengen_US
dc.source.urihttps://www.ijdvl.comen_US
dc.subject.meshAdulten_US
dc.subject.meshBiopsy, Needleen_US
dc.subject.meshCryotherapy --methodsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshElastic Tissue --pathologyen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHepatolenticular Degeneration --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshPenicillamine --adverse effectsen_US
dc.subject.meshPseudoxanthoma Elasticum --chemically induceden_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTreatment Outcomeen_US
dc.titlePenicillamine induced pseudoxanthoma elasticum with elastosis perforans serpiginosa.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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