The beneficial role of N-acetylcysteine as an adjunctive drug in treatment of COVID-19 patients in a tertiary care hospital in India: an observational study
dc.contributor.author | Bhattacharya, Raja | en_US |
dc.contributor.author | Mondal, Maitry | en_US |
dc.contributor.author | Naiya, Subhendu Bikash | en_US |
dc.contributor.author | Lyngdoh, Lamsaka | en_US |
dc.contributor.author | Mukherjee, Rishav | en_US |
dc.contributor.author | Singh, Prabhat K. | en_US |
dc.date.accessioned | 2020-11-18T10:02:35Z | |
dc.date.available | 2020-11-18T10:02:35Z | |
dc.date.issued | 2020-10 | |
dc.description.abstract | Background: N-acetyl cysteine, a mucolytic agent, demonstrates free radical scavenging and anti-inflammatory properties, and prevents endothelial dysfunction by inhibition of NF-KB and formation of no adducts. This has a potential role to tackle cytokine storms, endothelial dysfunction and prothrombotic state observed in COVID-19 manifestations like ARDS and Multi organ dysfunction.Methods: Institution based descriptive cross sectional study, 164 patients from laboratory confirmed RT PCR positive COVID-19 patients, in the study period from 27th May 2020 to 10th August 2020, were assessed, in medical college Kolkata, a dedicated COVID-19 care facility.Results: It was observed that moderate-severe patients who received N-acetyl cysteine along with standard therapy had average hospital stay duration of 12 days, higher rate of discharge, average duration of oxygen therapy of 8 days, less number of deaths and reduced transfer to critical care facilities.Conclusions: N-acetyl cysteine can be considered as an adjunctive therapy with standard protocol driven care, due to its beneficial anti-inflammatory and free radical scavenging properties. | en_US |
dc.identifier.affiliations | Department of Medicine, Medical College and Hospital, Kolkata, West Bengal, India | en_US |
dc.identifier.affiliations | Marwari Relief Society, Kolkata, West Bengal, India | en_US |
dc.identifier.citation | Bhattacharya Raja, Mondal Maitry, Naiya Subhendu Bikash, Lyngdoh Lamsaka, Mukherjee Rishav, Singh Prabhat K.. The beneficial role of N-acetylcysteine as an adjunctive drug in treatment of COVID-19 patients in a tertiary care hospital in India: an observational study. International Journal of Research in Medical Sciences. 2020 Oct; 8(10): 3518-3522 | en_US |
dc.identifier.issn | 2320-6071 | |
dc.identifier.issn | 2320-6012 | |
dc.identifier.place | India | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/212634 | |
dc.language | en | en_US |
dc.publisher | Medip Academy | en_US |
dc.relation.issuenumber | 10 | en_US |
dc.relation.volume | 8 | en_US |
dc.source.uri | https://dx.doi.org/10.18203/2320-6012.ijrms20204010 | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | N-acetyl cysteine | en_US |
dc.subject | Free radical scavenger | en_US |
dc.subject | Anti-inflammatory | en_US |
dc.title | The beneficial role of N-acetylcysteine as an adjunctive drug in treatment of COVID-19 patients in a tertiary care hospital in India: an observational study | en_US |
dc.type | Journal Article | en_US |
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