The beneficial role of N-acetylcysteine as an adjunctive drug in treatment of COVID-19 patients in a tertiary care hospital in India: an observational study

Simple item page
dc.contributor.authorBhattacharya, Rajaen_US
dc.contributor.authorMondal, Maitryen_US
dc.contributor.authorNaiya, Subhendu Bikashen_US
dc.contributor.authorLyngdoh, Lamsakaen_US
dc.contributor.authorMukherjee, Rishaven_US
dc.contributor.authorSingh, Prabhat K.en_US
dc.date.accessioned2020-11-18T10:02:35Z
dc.date.available2020-11-18T10:02:35Z
dc.date.issued2020-10
dc.description.abstractBackground: N-acetyl cysteine, a mucolytic agent, demonstrates free radical scavenging and anti-inflammatory properties, and prevents endothelial dysfunction by inhibition of NF-KB and formation of no adducts. This has a potential role to tackle cytokine storms, endothelial dysfunction and prothrombotic state observed in COVID-19 manifestations like ARDS and Multi organ dysfunction.Methods: Institution based descriptive cross sectional study, 164 patients from laboratory confirmed RT PCR positive COVID-19 patients, in the study period from 27th May 2020 to 10th August 2020, were assessed, in medical college Kolkata, a dedicated COVID-19 care facility.Results: It was observed that moderate-severe patients who received N-acetyl cysteine along with standard therapy had average hospital stay duration of 12 days, higher rate of discharge, average duration of oxygen therapy of 8 days, less number of deaths and reduced transfer to critical care facilities.Conclusions: N-acetyl cysteine can be considered as an adjunctive therapy with standard protocol driven care, due to its beneficial anti-inflammatory and free radical scavenging properties.en_US
dc.identifier.affiliationsDepartment of Medicine, Medical College and Hospital, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsMarwari Relief Society, Kolkata, West Bengal, Indiaen_US
dc.identifier.citationBhattacharya Raja, Mondal Maitry, Naiya Subhendu Bikash, Lyngdoh Lamsaka, Mukherjee Rishav, Singh Prabhat K.. The beneficial role of N-acetylcysteine as an adjunctive drug in treatment of COVID-19 patients in a tertiary care hospital in India: an observational study. International Journal of Research in Medical Sciences. 2020 Oct; 8(10): 3518-3522en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212634
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20204010en_US
dc.subjectCOVID-19en_US
dc.subjectN-acetyl cysteineen_US
dc.subjectFree radical scavengeren_US
dc.subjectAnti-inflammatoryen_US
dc.titleThe beneficial role of N-acetylcysteine as an adjunctive drug in treatment of COVID-19 patients in a tertiary care hospital in India: an observational studyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijrms2020v8n10p3518.pdf
Size:
113.14 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Research in Medical Sciences