Helicobacter pylori-associated gastritis and gastric cancer in Nigeria.

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dc.contributor.authorOluwasola, A Oen_US
dc.contributor.authorOgunbiyi, J Oen_US
dc.date.accessioned2003-11-20en_US
dc.date.accessioned2009-05-29T03:26:06Z
dc.date.available2003-11-20en_US
dc.date.available2009-05-29T03:26:06Z
dc.date.issued2003-11-20en_US
dc.description.abstractBACKGROUND: The etiology of gastric cancer has not been clearly delineated. There is some evidence of an association of gastric cancer with Helicobacter pylori-induced chronic gastritis, atrophic gastritis and intestinal metaplasia. Previous studies report a high rate of H. pylori infection and chronic gastritis among Nigerians. METHODS: We retrospectively reviewed 84 tissue specimens with gastric cancer seen in our department over an 18-year period for for the presence of H. pylori infection, chronic gastritis, atrophic gastritis, and intestinal metaplasia in the adjacent non-cancerous gastric mucosa. RESULTS: H. pylori infection was detected in 15 (17.9%) of 84 specimens. Moderate to severe gastritis was found in non-cancerous areas in 77 (91.7%) specimens, and was equally frequent in patients with 'intestinal' and 'diffuse' types of cancer. Atrophic gastritis and intestinal metaplasia were observed in 22 (26.2%) and 35 (41.7%) specimens, respectively, and were more common in 'intestinal' type of gastric cancer. CONCLUSION: Chronic gastritis was seen in the adjacent non-cancerous mucosa in most specimens with gastric cancer. However, its severity did not correlate with the histological subtype of gastric cancer.en_US
dc.description.affiliationDepartment of Pathology, University of Ibadan, PMB 5116 Ibadan, Nigeria. oluwasol@yahoo.comen_US
dc.identifier.citationOluwasola AO, Ogunbiyi JO. Helicobacter pylori-associated gastritis and gastric cancer in Nigeria. Indian Journal of Gastroenterology. 2003 Nov-Dec; 22(6): 212-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/65333
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdenocarcinoma --epidemiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastritis --epidemiologyen_US
dc.subject.meshHelicobacter Infections --epidemiologyen_US
dc.subject.meshHelicobacter pylori --isolation & purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNigeria --epidemiologyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshStomach Neoplasms --epidemiologyen_US
dc.titleHelicobacter pylori-associated gastritis and gastric cancer in Nigeria.en_US
dc.typeJournal Articleen_US
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