Case report: Diazepam in severe tetanus treatment.

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dc.contributor.authorIsmoedijanto,en_US
dc.contributor.authorNassiruddin, Men_US
dc.contributor.authorPrajitno, B Wahyuen_US
dc.date.accessioned2009-05-27T14:36:26Z
dc.date.available2009-05-27T14:36:26Z
dc.date.issued2004-03-27en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe causes of death in tetanus are muscle spasms and spasm of the larynx, which are caused by blocking the release of inhibitory neurotransmitters in the spinal synapses, causing the uncontrolled spread of impulses. Diazepam controls the spasms by blocking the polysynaptic reflexes, working peripherally, without depressing the cortical center and has no cardiovascular or endocrine effects. High dose diazepam had been used and proved to be a good muscle relaxant. Diazepam seems to work better with tetanus than pancuronium bromide, but both drugs need mechanical ventilation. In cases where the dose exceeds 240 mg per day in a child, a ventilator should be on hand, and if the dose required is more than 480 mg per day, other drugs should be considered. In three cases of severe tetanus presented here, the first two were managed by diazepam and pancuronium bromide and the last case by high dose diazepam only. In the first case, the dose of diazepam was up to 480 mg/day. By using high dose diazepam in severe tetanus, management of the clinical manifestations of autonomic nerve involvement and the weaning process become easier. Most complications of severe tetanus became more manageable.en_US
dc.description.affiliationDepartment of Child Health, Faculty of Medicine, Airlangga University, Surabaya, Indonesia. ismoe@indosat.net.iden_US
dc.identifier.citationIsmoedijanto , Nassiruddin M, Prajitno BW. Case report: Diazepam in severe tetanus treatment. The Southeast Asian Journal of Tropical Medicine and Public Health. 2004 Mar; 35(1): 175-80en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30586
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2004_35_1/29-3081.pdfen_US
dc.subject.meshAnticonvulsants --administration & dosageen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDiazepam --administration & dosageen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshIndonesiaen_US
dc.subject.meshMaleen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSampling Studiesen_US
dc.subject.meshSeizures --complicationsen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshTetanus --complicationsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleCase report: Diazepam in severe tetanus treatment.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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