Re-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy.

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dc.contributor.authorPandey, G Sen_US
dc.contributor.authorKesari, Aen_US
dc.contributor.authorMukherjee, Men_US
dc.contributor.authorMittal, R Den_US
dc.contributor.authorMittal, Ben_US
dc.date.accessioned2003-09-04en_US
dc.date.accessioned2009-06-03T11:05:44Z
dc.date.available2003-09-04en_US
dc.date.available2009-06-03T11:05:44Z
dc.date.issued2003-09-04en_US
dc.description.abstractThe reading frame hypothesis has been proposed to explain the molecular basis of two allelic forms of muscular dystrophies, Duchenne/Becker muscular dystrophy (D/BMD). To evaluate the hypothesis in Indian D/BMD patients, we analyzed deletion of dystrophin exons in 147 DMD and 19 BMD patients. Our studies showed deviation of more than 30% from the reading frame hypothesis in DMD patients (47/147). The present results implicate a need to reevaluate the reading frame hypothesis.en_US
dc.description.affiliationDepartment of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow - 226014, India.en_US
dc.identifier.citationPandey GS, Kesari A, Mukherjee M, Mittal RD, Mittal B. Re-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy. Neurology India. 2003 Sep; 51(3): 367-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/120661
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshChilden_US
dc.subject.meshDystrophin --geneticsen_US
dc.subject.meshFrameshift Mutationen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscular Dystrophy, Duchenne --geneticsen_US
dc.subject.meshPhenotypeen_US
dc.titleRe-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy.en_US
dc.typeJournal Articleen_US
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