Risk factors for nosocomial infections caused by extended-spectrum β-lactamase producing Escherichia coli or Klebsiella pneumoniae in Thailand

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dc.contributor.authorPairoj Saonuamen_US
dc.contributor.authorNarin Hiransuthikulen_US
dc.contributor.authorChusana Suankratayen_US
dc.contributor.authorKumthorn Malathumen_US
dc.contributor.authorSomwang Danchaivijitren_US
dc.date.accessioned2011-02-15T08:41:39Z
dc.date.available2011-02-15T08:41:39Z
dc.date.created2010-01-26en_US
dc.date.issued2010-01-26en_US
dc.description.abstractBackground and objective: Extended-spectrum β-lactamase (ESBL)-producing organisms have been reported among nosocomial pathogens. The objective of this study is to determine the risk factors for nosocomial infections in adults caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E-coli) or Klebsiella pneumoniae (K. pneumoniae) in regional and provincial government hospitals in Thailand.Methods: A nested case-control study was conducted, and the patients were enrolled between July 1 and December 31, 2007. We compared 288 patients with nosocomial infections caused by ESBL-producing E. coli or K. pneumoniae to 288 hospital-matched controls with nosocomial infections caused by non ESBL-producing E. coli or K. pneumoniae.Results: The independent risk factors associated with nosocomial infections caused by ESBL producing strains included Charlson comorbidity index (Odds ratio=1.18, 95% confidence interval (CI) =1.06-1.31, p-value=0.001) and previous third generation cephalosporin use (OR=4.82, 95% CI=3.23-7.21, p-value \< 0.001).Conclusion: This is the first nested case-control study regarding the risk factors of nosocomial infections caused by ESBL-producing organisms. The Charlson comorbidity index and previous third-generation cephalosporin use were the contributing factors of nosocomial infections caused by these organisms. An emphasis on appropriate use of the third-generation cephalosporins as well as effective infection control measures in patients with high comorbidity index are needed to reduce the incidence of nosocomial infections caused by these organisms.en_US
dc.identifier.citationAsian Biomedicine (Research Reviews and News); Vol. 2 No. 6 December 2008; 485-491en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/130061
dc.language.isoen_USen_US
dc.publisherAsian Biomedicine (Research Reviews and News)en_US
dc.rightsAsian Biomedicine (Research Reviews and News)en_US
dc.source.urihttps://abm.digitaljournals.org/index.php/abm/article/viewFile/221/140en_US
dc.titleRisk factors for nosocomial infections caused by extended-spectrum β-lactamase producing Escherichia coli or Klebsiella pneumoniae in Thailanden_US
dc.typeOriginal articleen_US
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