The efficacy of unoprostone isopropyl as an adjunct to topical beta-blocker in patients with open angle glaucoma: a-6-month study.
dc.contributor.author | Leelachaikul, Yupin | en_US |
dc.contributor.author | Euswas, Ataya | en_US |
dc.date.accessioned | 2009-05-27T18:01:33Z | |
dc.date.available | 2009-05-27T18:01:33Z | |
dc.date.issued | 2005-11-10 | en_US |
dc.description | Chotmaihet Thangphaet. | en_US |
dc.description.abstract | OBJECTIVES: To assess the efficacy and safety of unoprostone isopropyl as an adjunctive treatment to topical beta-blocker in patients with primary open angle glaucoma (POAG). STUDY DESIGN: This was a prospective, open-label clinical study. MATERIAL AND METHOD: A total of 44 eyes of 22 eligible patients whose intraocular pressure (IOP) was inadequately controlled by topical beta-blocker were enrolled. Inclusion criteria consisted of patients with primary open angle glaucoma who either had IOP measurements > or = 22 mmHg while on topical beta-blocker monotherapy or had IOP measurements > or = 18 mmHg while on dual therapy (topical beta-blocker and a second drug of a different class which was to be discontinued prior to the study to allow washing out of its effects). INTERVENTION: Baseline IOP, pupil size, blood pressure and pulse rate were initially measured; the patients were then examined at 2nd, 4th, 8th, 12th, 18th and 24th weeks of following commencement of topical unoprostone isopropyl therapy (given twice daily). MAIN OUTCOME MEASURES: IOP pupil size, blood pressure and pulse rate were measured and were compared to baseline values. RESULTS: In 44 eyes of 22 eligible patients, unoprostone isopropyl resulted in a statistically significant IOP reduction of 24.6% (p < 0.02). The mean systolic blood pressure decreased from 132.79 +/- 22.11 mmHg (range 100-180 mmHg) at baseline to 125.77 +/- 18.40 mmHg (range 80-160 mmHg) at 24th week after unoprostone isopropyl administration. This reduction was statistically significant (p = 0.002) but was unlikely to have clinical importance. Both mean diastolic blood pressure (p = 0.344), pulse rate (p = 0.306), and pupil diameter (p = 0.107) were not significantly affected. CONCLUSION: Topical unoprostone isopropyl beneficially provides additive IOP lowering effect to topical beta-blocker in patients with primary open angle glaucoma. No serious systemic side effects were found in the present study. | en_US |
dc.description.affiliation | Department of Ophthalmology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. rapll@mucc.mahidol.ac.th | en_US |
dc.identifier.citation | Leelachaikul Y, Euswas A. The efficacy of unoprostone isopropyl as an adjunct to topical beta-blocker in patients with open angle glaucoma: a-6-month study. Journal of the Medical Association of Thailand. 2005 Nov; 88 Suppl 9(): S100-4 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/38299 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.mat.or.th/journal/all.php | en_US |
dc.subject.mesh | Administration, Topical | en_US |
dc.subject.mesh | Adrenergic beta-Antagonists --administration & dosage | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 and over | en_US |
dc.subject.mesh | Dinoprost --administration & dosage | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Drug Therapy, Combination | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Follow-Up Studies | en_US |
dc.subject.mesh | Glaucoma, Open-Angle --diagnosis | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Intraocular Pressure | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Ophthalmic Solutions | en_US |
dc.subject.mesh | Prospective Studies | en_US |
dc.subject.mesh | Risk Assessment | en_US |
dc.subject.mesh | Severity of Illness Index | en_US |
dc.subject.mesh | Single-Blind Method | en_US |
dc.subject.mesh | Tonometry, Ocular | en_US |
dc.subject.mesh | Treatment Outcome | en_US |
dc.title | The efficacy of unoprostone isopropyl as an adjunct to topical beta-blocker in patients with open angle glaucoma: a-6-month study. | en_US |
dc.type | Clinical Trial | en_US |
dc.type | Journal Article | en_US |
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