Central nervous system tuberculosis and adjuvant corticosteroid therapy.

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dc.contributor.authorRahman, M Len_US
dc.contributor.authorBasher, Aen_US
dc.contributor.authorRashid, Men_US
dc.contributor.authorIslam, Men_US
dc.contributor.authorKuddus, Ren_US
dc.contributor.authorArif, S Men_US
dc.contributor.authorFaiz, M Aen_US
dc.date.accessioned2009-01-03en_US
dc.date.accessioned2009-05-27T03:53:03Z
dc.date.available2009-01-03en_US
dc.date.available2009-05-27T03:53:03Z
dc.date.issued2009-01-03en_US
dc.descriptionMymensingh Medical Journal.en_US
dc.description.abstractTuberculous involvement of central nervous system is one of the important health issues causing high mortality and morbidity. Uncertainty and doubt dominate all aspects of CNS tuberculosis. Diagnosis is mainly based on clinical features, cerebrospinal fluid changes, and imaging characteristics. Few studies have shown that corticosteroids improve the clinical outcome, although the precise mechanism of action remains tentative. All the cases were selected on strong clinical suspicion of CNS tuberculosis. They were graded according to tuberculous meningitis (TM) severity grades. In this connection, we studied 13 patients in one medicine unit over 12 month's period to see the effect of corticosteroid as part of the outcome. Nine patients (69.23%) were in grade II, three (23.08%) patients were in grade III, and one (7.69%) was in grade I. Seven patients (53.85%) had tuberculous meningitis and six (46.15%) had tuberculoma (CT or MRI). Out of 13 cases 3 patients (23%) died in the hospital and 10 patients (77%) improved, of whom 2 patients (20%) recovered completely and 8 patients (80%) had residual neurological deficit. Our study suggests that the early detection of CNS tuberculosis is the most important prognostic factor. Timely started anti-Koch's treatment with adjuvant corticosteroid therapy has a direct bearing on patient outcome.en_US
dc.description.affiliationDr Sardar Md Lutfur Rahman, IMO, Department of Medicine, Dhaka Medical College & Hospital, Dhaka, Bangladesh.en_US
dc.identifier.citationRahman ML, Basher A, Rashid M, Islam M, Kuddus R, Arif SM, Faiz MA. Central nervous system tuberculosis and adjuvant corticosteroid therapy. Mymensingh Medical Journal. 2009 Jan; 18(1): 47-51en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/1247
dc.language.isoengen_US
dc.titleCentral nervous system tuberculosis and adjuvant corticosteroid therapy.en_US
dc.typeJournal Articleen_US
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