Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase

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dc.contributor.authorBose, Arnaben_US
dc.contributor.authorSudevan, Surabhien_US
dc.contributor.authorRao, Vinay Jen_US
dc.contributor.authorShima, Hirokien_US
dc.contributor.authorTrivedi, Arun Kumaren_US
dc.contributor.authorIgarashi, Kazuhikoen_US
dc.contributor.authorKundu, Tapas Ken_US
dc.date.accessioned2020-11-18T10:14:14Z
dc.date.available2020-11-18T10:14:14Z
dc.date.issued2019-12
dc.description.abstractThe Aurora kinases represent a group of serine/threonine kinases which are crucial regulators of mitosis. DysregulatedAurora kinase B (AurkB) expression, stemming from genomic amplification, increased gene transcription or overexpressionof its allosteric activators, is capable of initiating and sustaining malignant phenotypes. Although AurkB level in cells iswell-orchestrated, studies that relate to its stability or activity, independent of mitosis, are lacking. We report that AurkBundergoes acetylation in vitro by lysine acetyltransferases (KATs) belonging to different families, namely by p300 andTip60. The haploinsufficient tumor suppressor Tip60 acetylates two highly conserved lysine residues within the kinasedomain of AurkB which not only impinges the protein stability but also its kinase activity. These results signify a probableoutcome on the increase in ‘‘overall activity’’ of AurkB upon Tip60 downregulation, as observed under cancerous conditions. The present work, therefore, uncovers an important functional interplay between AurkB and Tip60, frailty of whichmay be an initial event in carcinogenesis.en_US
dc.identifier.affiliationsTranscription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsTranscription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsTranscription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Tohoku University Graduate School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai 980-8575, Japanen_US
dc.identifier.affiliationsDivision of Cancer Biology, CSIR-Central Drug Research Institute (CSIR-CDRI), Sector-10, Jankipuram Extension, Lucknow, UP 226031, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Tohoku University Graduate School of Medicine, Seiryo-machi 2-1, Aoba-ku, Sendai 980-8575, Japanen_US
dc.identifier.affiliationsTranscription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, Karnataka, Indiaen_US
dc.identifier.citationBose Arnab, Sudevan Surabhi, Rao Vinay J, Shima Hiroki, Trivedi Arun Kumar, Igarashi Kazuhiko, Kundu Tapas K. Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase. Journal of Biosciences. 2019 Dec; 44(6): 1-8en_US
dc.identifier.issn0250-5991
dc.identifier.issn0973-7138
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214214
dc.languageenen_US
dc.publisherIndian Academy of Sciencesen_US
dc.relation.issuenumber6en_US
dc.relation.volume44en_US
dc.source.urihttps://dx.doi.org//10.1007/s12038-019-9963-6en_US
dc.subjectAurkBen_US
dc.subjectacetylationen_US
dc.subjectkinase activityen_US
dc.subjectstabilityen_US
dc.subjectTip60en_US
dc.titleHaploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinaseen_US
dc.typeJournal Articleen_US
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