Comparison of long-term outcomes of trabeculectomy and risk factors for failure in eyes post penetrating keratoplasty or Descemet’s stripping endothelial keratoplasty

Simple item page
dc.contributor.authorSenthil, Sirishaen_US
dc.contributor.authorRao, Harsha Len_US
dc.contributor.authorAli, Mohammed Hasnaten_US
dc.contributor.authorKrishnamurthy, Rashmien_US
dc.contributor.authorDikshit, Siddharthen_US
dc.contributor.authorChoudhari, Nikhilen_US
dc.contributor.authorSastry, Ramyasrien_US
dc.contributor.authorGarudadri, Chandrashekaren_US
dc.date.accessioned2023-08-25T06:32:23Z
dc.date.available2023-08-25T06:32:23Z
dc.date.issued2022-03
dc.description.abstractPurpose: To evaluate the outcomes of trabeculectomy, graft survival, and risk factors for failure in post penetrating keratoplasty (PK) and Descemet’s stripping endothelial keratoplasty (DSEK) eyes. Methods: We reviewed charts of eyes that underwent trabeculectomy for post keratoplasty glaucoma PK [25 eyes] and DSEK [14 eyes] between 1993 and 2019. The demographics, clinical features, and surgical outcomes were evaluated. Success of trabeculectomy was defined as complete when the intraocular pressure (IOP) was >5 and ?21 mmHg without antiglaucoma medications (AGM) and qualified with AGM. Clear and compact graft was considered for graft success. Results: Median (interquartile range [IQR] preoperative IOP in post?PK eyes and post?DSEK eyes was comparable, 32 (28–38) vs. 31.5 (25–36) mmHg, P = 0.38). Median number of preoperative AGMs was comparable (P = 0.78). Median postoperative follow?up was longer in post?PK, compared with post?DSEK, 2.5 (1.3–3.3) vs. 1 (0.3–2.9) years (P = 0.05). Kaplan–Meier survival estimates for complete and qualified success of trabeculectomy at 3 years were 23.7% and 73.3%, respectively, for PK and 45.8% and 71.6%, respectively, for DSEK. Kaplan–Meier survival estimates for graft survival were 91.8% up to 3 years for PK and 100% until 2 years and 77.8% at 3 years for DSEK. Higher IOP prior to trabeculectomy was a risk factor for failure of trabeculectomy (P = 0.03) and older age was a risk factor for graft failure (P = 0.05) in PK eyes. Number of prior corneal surgeries (P = 0.05) was associated with failure of trabeculectomy and graft failure in post?DSEK eyes. Conclusion: Trabeculectomy had moderate qualified success in post?PK and DSEK eyes at 3 years. Higher pretrabeculectomy IOP and higher number of prior corneal surgeries were significantly associated with failure of trabeculectomy in PK and DSEK eyes, respectivelyen_US
dc.identifier.affiliationsVST Centre for Glaucoma, L V Prasad Eye Institute, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsOphthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsThe Cornea Institute, L V Prasad Eye Institute, Hyderabad, Telangana, Indiaen_US
dc.identifier.citationSenthil Sirisha, Rao Harsha L, Ali Mohammed Hasnat, Krishnamurthy Rashmi, Dikshit Siddharth, Choudhari Nikhil, Sastry Ramyasri, Garudadri Chandrashekar. Comparison of long-term outcomes of trabeculectomy and risk factors for failure in eyes post penetrating keratoplasty or Descemet’s stripping endothelial keratoplasty. Indian Journal of Ophthalmology. 2022 Mar; 70(3): 827-833en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224230
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber3en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_1213_21en_US
dc.subjectDescemet’s stripping endothelial keratoplastyen_US
dc.subjectglaucomaen_US
dc.subjectgraft survivalen_US
dc.subjectpenetrating keratoplastyen_US
dc.subjecttrabeculectomy successen_US
dc.titleComparison of long-term outcomes of trabeculectomy and risk factors for failure in eyes post penetrating keratoplasty or Descemet’s stripping endothelial keratoplastyen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJO2022v70n3p827.pdf
Size:
1.33 MB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Ophthalmology