Video-dermoscopic Assessment of Capillaroscopic Pattern in Hansen's Disease

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dc.contributor.authorSudhakar, Rao KMen_US
dc.contributor.authorSmitha, SVen_US
dc.contributor.authorAruna, MSen_US
dc.date.accessioned2023-08-09T06:22:19Z
dc.date.available2023-08-09T06:22:19Z
dc.date.issued2022-06
dc.description.abstractLeprosy is a chronic granulomatous infectious disease with a proven role of Mycobacterium leprae invasion into endothelial cells. Animal studies have shown evidence of involvement of vasa nervorum in the process of nerve invasion. Capillaries act as the mirror image of vascular involvement in any rheumatic disorder and holds good for leprosy also. Nailfold capillaroscopy (NFC) is a non-invasive, easily reproducible technique to study proximal nailfold capillaries. The aim of this study is to investigate morphological nailfold capillaroscopic alterations in patients with leprosy in its various forms and comparison with the normal individual. Total 20 Leprosy patients and 20 normal age and sex matched individuals recruited for nailfold capillaroscopic examination using video dermoscopye. Among 20 normal individuals, 3(15%) individuals showed tortuous capillaries and microhemorrhages each, 2(10%) showed meandering vessels, 1(5%) each showed megacapillaries, dilated/ectatic capillaries and bizarre vessels. Out of 20 leprosy patients, 11 (55%) patients showed bizarre and meandering capillaries, 10(50%) showed dilated vessels and avascular areas, 9(45%) showed capillary dropouts and neovascularisation, 8(40%) showed tortuous vessels, 6(30%) haemorrhages and 4 (20%) showed megacapillaries. Findings like avascular areas, capillary dropouts, haemorrhages were more noticed in lepromatous and borderline lepromatous leprosy, whereas early capillary abnormalities like dilated, meandering, bizarre vessels and neoangiogenesis were noticed more in borderline tuberculoid leprosy. However, statistical significant difference between clinical and dermoscopic observations was not seen in this study. Further studies with a large sample size are required to find out the same. Morphological changes may denote micro-vascular invasion by Mycobacterium leprae and may act as warning signs of fore- coming complications like loss of sensation and trophic ulcers. Follow-up studies are required to understand such correlation, if any.en_US
dc.identifier.affiliationsProfessor,en_US
dc.identifier.affiliationsJunior Residenten_US
dc.identifier.affiliationsAssistant Professor, Department of Community Medicine, Kurnool Medical College, Kurnool, Andhra Pradesh-518005, Indiaen_US
dc.identifier.affiliationsJunior Resident Department of Dermatology, Venereology and Leprosy, SNMC and HSK Hospital Navanagar, Bagalkot, Karnataka- 587102, Indiaen_US
dc.identifier.citationSudhakar Rao KM, Smitha SV, Aruna MS. Video-dermoscopic Assessment of Capillaroscopic Pattern in Hansen's Disease. Indian Journal of Leprosy. 2022 Jun; 94: 153-161en_US
dc.identifier.issn0254-9395
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222602
dc.languageenen_US
dc.publisherHind Kusht Nivaran Sangh (Indian Leprosy Association)en_US
dc.relation.volume94en_US
dc.source.urihttps://www.ijl.org.in/article-detail/94/418en_US
dc.subjectLeprosyen_US
dc.subjectHansen's Diseaseen_US
dc.subjectNailfold-capillaroscopyen_US
dc.subjectVideo-dermoscopeen_US
dc.subjectVasa nervorum, Meanderingen_US
dc.subjectBizarreen_US
dc.subjectAvascular areasen_US
dc.titleVideo-dermoscopic Assessment of Capillaroscopic Pattern in Hansen's Diseaseen_US
dc.typeJournal Articleen_US
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