Current antibiotic use in the treatment of enteric fever in children

Simple item page
dc.contributor.authorDahiya, Sen_US
dc.contributor.authorMalik, Ren_US
dc.contributor.authorSharma, Pen_US
dc.contributor.authorSashi, Aen_US
dc.contributor.authorLodha, Ren_US
dc.contributor.authorKabra, SKen_US
dc.contributor.authorSood, Sen_US
dc.contributor.authorDas, BKen_US
dc.contributor.authorWalia, Ken_US
dc.contributor.authorOhri, V Cen_US
dc.contributor.authorKapil, Aen_US
dc.date.accessioned2020-04-10T01:41:46Z
dc.date.available2020-04-10T01:41:46Z
dc.date.issued2019-02
dc.description.abstractBackground & objectives: Antimicrobial resistance is a major challenge in the treatment of typhoid fever with limited choices left to empirically treat these patients. The present study was undertaken to determine the current practices of antibiotic use in children attending a tertiary care hospital in north India. Methods: This was a descriptive observational study in children suffering from enteric fever as per the case definition including clinical and laboratory parameters. The antibiotic audit in hospitalized children was measured as days of therapy per 1000 patient days and in outpatient department (OPD) as antibiotic prescription on the treatment card. Results: A total of 128 children with enteric fever were included in the study, of whom, 30 were hospitalized and 98 were treated from OPD. The mean duration of fever was 9.5 days at the time of presentation. Of these, 45 per cent were culture positive with Salmonella Typhi being aetiological agent in 68 per cent followed by S. Paratyphi A in 32 per cent. During hospitalization, the average length of stay was 10 days with mean duration of defervescence 6.4 days. Based on antimicrobial susceptibility ceftriaxone was given to 28 patients with mean duration of treatment being six days. An additional antibiotic was needed in six patients due to clinical non-response. In OPD, 79 patients were prescribed cefixime and additional antibiotic was needed in five during follow up visit. Interpretation & conclusions: Based on our findings, ceftriaxone and cefixime seemed to be the first line of antibiotic treatment for typhoid fever. Despite susceptibility, clinical non-response was seen in around 10 per cent of the patients who needed combinations of antibiotics.en_US
dc.identifier.affiliationsDepartment of Microbiology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrics, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDivision of Epidemiology & Communicable Diseases, Indian Council of Medical Research, New Delhi, Indiaen_US
dc.identifier.citationDahiya S, Malik R, Sharma P, Sashi A, Lodha R, Kabra SK, Sood S, Das BK, Walia K, Ohri V C, Kapil A. Current antibiotic use in the treatment of enteric fever in children. Indian Journal of Medical Research. 2019 Feb; 149(2): 263-269en_US
dc.identifier.issn0971-5916
dc.identifier.issn0975-9174
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/195803
dc.languageenen_US
dc.publisherIndian Council of Medical Researchen_US
dc.relation.issuenumber2en_US
dc.relation.volume149en_US
dc.source.urihttps://dx.doi.org/10.4103/ijmr.IJMR_199_18en_US
dc.subjectAntibiotic useen_US
dc.subjectdays of therapyen_US
dc.subjectenteric feveren_US
dc.subjectSalmonella Typhien_US
dc.titleCurrent antibiotic use in the treatment of enteric fever in childrenen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijmr2019v149n2p263.pdf
Size:
433.27 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Medical Research