Randomized trial of a quadruple-drug regimen and a triple-drug regimen for eradication of Helicobacter pylori: long-term follow-up study.

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dc.contributor.authorKumar, Den_US
dc.contributor.authorAhuja, Ven_US
dc.contributor.authorDhar, Aen_US
dc.contributor.authorSharma, M Pen_US
dc.date.accessioned2001-09-26en_US
dc.date.accessioned2009-05-29T02:03:45Z
dc.date.available2001-09-26en_US
dc.date.available2009-05-29T02:03:45Z
dc.date.issued2001-09-26en_US
dc.description.abstractBACKGROUND: In developing countries, H. pylori eradication rates are suboptimal. A quadruple-drug regimen may improve on the eradication rate achieved with triple-drug regimen. METHODS: 64 consecutive patients with active duodenal ulcer associated with H. pylori infection were randomized to receive either a one-week triple-drug regimen (lansoprazole, clarithromycin, secnidazole) or a one-week quadruple-drug regimen (lansoprazole, amoxycillin, colloidal bismuth subcitrate, secnidazole). H. pylori eradication and ulcer healing were assessed 4 weeks after completion of therapy. Patients were followed up at 24 weeks and 52 weeks for H. pylori recurrence. RESULTS: Both the regimens eradicated H. pylori in 75% (95% CI 0.6-0.9) of patients. The ulcer-healing rate with the triple-drug regimen was 97% (95% CI 0.91-1.0) and 91% (95% CI 0.91-1.0) with the quadruple-drug regimen. No ulcer or H. pylori recurrence occurred in patients eradicated with the triple-drug regimen, whereas 8.3% of patients eradicated with the quadruple-drug regimen had ulcer as well as H. pylori recurrence during the 52-week follow up. CONCLUSION: Triple-drug regimen achieves similar eradication rates as quadruple-drug regimen in H. pylori infection.en_US
dc.description.affiliationDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationKumar D, Ahuja V, Dhar A, Sharma MP. Randomized trial of a quadruple-drug regimen and a triple-drug regimen for eradication of Helicobacter pylori: long-term follow-up study. Indian Journal of Gastroenterology. 2001 Sep-Oct; 20(5): 191-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63689
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.mesh2-Pyridinylmethylsulfinylbenzimidazolesen_US
dc.subject.meshAdulten_US
dc.subject.meshAmoxicillin --administration & dosageen_US
dc.subject.meshAnti-Bacterial Agents --administration & dosageen_US
dc.subject.meshAntiprotozoal Agents --administration & dosageen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshClarithromycin --administration & dosageen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshDuodenal Ulcer --drug therapyen_US
dc.subject.meshEndoscopy, Gastrointestinalen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHelicobacter Infections --drug therapyen_US
dc.subject.meshHelicobacter pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshLongitudinal Studiesen_US
dc.subject.meshMaleen_US
dc.subject.meshMetronidazole --administration & dosageen_US
dc.subject.meshOmeprazole --administration & dosageen_US
dc.subject.meshOrganometallic Compounds --administration & dosageen_US
dc.subject.meshPenicillins --administration & dosageen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleRandomized trial of a quadruple-drug regimen and a triple-drug regimen for eradication of Helicobacter pylori: long-term follow-up study.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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