An adaptive clinical trial on patients with non variceal upper gastrointestinal bleed with the help of endoscopy

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dc.contributor.authorSingh, Premen_US
dc.contributor.authorSingh, Gauraven_US
dc.contributor.authorKumar, Vinayen_US
dc.contributor.authorChawla, Gauraven_US
dc.date.accessioned2020-04-09T07:43:52Z
dc.date.available2020-04-09T07:43:52Z
dc.date.issued2020-03
dc.description.abstractBackground: Acute upper gastrointestinal hemorrhage (UGIH) is a common condition worldwide frequently leads to hospital admission also has a significant associated morbidity and mortality, especially in the elderly. A systematic diagnostic and definite therapeutic approach is essential to establish a diagnosis, relevant to specific investigations for appropriate treatment in tertiary medical care center.Methods: A comparative trial was done on n=109 cases with an objective to find out the different causes of UGI bleed in population, to assess the requirement of blood transfusion in patients with massive GI Bleed and to compare the treatment outcome of Proton pump inhibitors over Tranexamic acid and Octreotide in non-variceal UGI bleed. The cases were assigned to three different groups by lottery system. Proton pump inhibitors (Omeprazole), Somatostatin (Octreotide), Anti-fibrinolytic (Tranexamic acid), outcome was assessed after complete treatment and follow up.Results: Out of 150 cases, 109 were diagnosed with non-variceal GI bleed, 35 cases were treated with Omeprazole out of which 11.42% cases received blood transfusion, and 4 had history of re bleeding, Mean Duration of stay in hospital was 4.4±1.75, when compared to the other two group the duration of hospitalization was least as the P value was <0.0001.Conclusions: In this study it was demonstrated the use of PPI in case of Non-Variceal Bleeding significantly reduces the need of blood transfusion. Even it reduces the cases of re bleeding and duration of hospital stay.en_US
dc.identifier.affiliationsDepartment of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Gastroenterology, Kanpur Medical Centre Pvt Ltd., Kanpur, Uttar Pradesh, Indiaen_US
dc.identifier.citationSingh Prem, Singh Gaurav, Kumar Vinay, Chawla Gaurav. An adaptive clinical trial on patients with non variceal upper gastrointestinal bleed with the help of endoscopy. International Journal of Advances in Medicine. 2020 Mar; 7(3): 435-438en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194610
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20200654en_US
dc.subjectAnti-fibrinolytic agenten_US
dc.subjectProton pump inhibitoren_US
dc.subjectSomatostatinen_US
dc.subjectUpper gastrointestinal bleeden_US
dc.titleAn adaptive clinical trial on patients with non variceal upper gastrointestinal bleed with the help of endoscopyen_US
dc.typeJournal Articleen_US
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