Status of lipid peroxidation and antioxidant enzymes in hypoxic ischemic encephalopathy.

Simple item page
dc.contributor.authorSingh, S Ken_US
dc.contributor.authorDua, Ten_US
dc.contributor.authorTandon, Aen_US
dc.contributor.authorKumari, Sen_US
dc.contributor.authorRay, Gen_US
dc.contributor.authorBatra, Sen_US
dc.date.accessioned1999-06-29en_US
dc.date.accessioned2009-05-27T05:06:54Z
dc.date.available1999-06-29en_US
dc.date.available2009-05-27T05:06:54Z
dc.date.issued1999-06-29en_US
dc.description.abstractOBJECTIVE: To compare the activities of key antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase] and the level of malonyl dialdehyde (MDA) in neonates with hypoxic ischemic encephalopathy (HIE) and controls. DESIGN: Prospective cross sectional study. SETTING: Tertiary care level II neonatal unit of teaching hospital. METHODS: Fifteen term new borns with HIE were registered for the study whereas normal term appropriate for gestational age babies were enrolled as controls. Clinical features were recorded. Activities of SOD, GPx, catalase and the content of MDA were estimated at 24 hours of age. The results obtained were statistically analyzed. RESULTS: Activities of SOD and Catalase and the level of MDA were significantly higher in cases as compared to the controls. There was however no significant alternation in the activity of GPx levels in both the groups. CONCLUSION: The increased activities of antioxidant enzymes are unable to counteract the excessively generated oxidants in vivo, as is evident from the increased MDA levels. Hence, oxygen free radicals may play a significant role in the pathogenesis of HIE.en_US
dc.description.affiliationDepartment of Pediatrics, Kalawati Saran Children Hospital, New Delhi-110 001, India.en_US
dc.identifier.citationSingh SK, Dua T, Tandon A, Kumari S, Ray G, Batra S. Status of lipid peroxidation and antioxidant enzymes in hypoxic ischemic encephalopathy. Indian Pediatrics. 1999 Jun; 36(6): 561-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/8311
dc.language.isoengen_US
dc.source.urihttps://indianpediatrics.neten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCatalase --metabolismen_US
dc.subject.meshGlutathione Peroxidase --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshHypoxia-Ischemia, Brain --enzymologyen_US
dc.subject.meshInfant, Newborn --metabolismen_US
dc.subject.meshLipid Peroxidation --physiologyen_US
dc.subject.meshMalondialdehyde --metabolismen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSuperoxide Dismutase --metabolismen_US
dc.titleStatus of lipid peroxidation and antioxidant enzymes in hypoxic ischemic encephalopathy.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Pediatrics