Clinical, biochemical and histological profile of nonalcoholic steatohepatitis.

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dc.contributor.authorAgarwal, S Ren_US
dc.contributor.authorMalhotra, Ven_US
dc.contributor.authorSakhuja, Pen_US
dc.contributor.authorSarin, S Ken_US
dc.date.accessioned2001-09-26en_US
dc.date.accessioned2009-05-29T02:58:29Z
dc.date.available2001-09-26en_US
dc.date.available2009-05-29T02:58:29Z
dc.date.issued2001-09-26en_US
dc.description.abstractBACKGROUND: Nonalcoholic steatohepatitis (NASH) has often been described in obese women with diabetes and/or hyperlipidemia. We evaluated the clinical, biochemical and histological profile of NASH. METHODS: 52 patients with persistently elevated ALT (>40 IU/L) for >6 months with no history of significant alcohol consumption and negative serological work-up for hepatitis B and C and HIV were enrolled. Twenty-five patients were diagnosed as having NASH and their clinical, biochemical, and histological profile was evaluated. RESULTS: Of the 25 patients with NASH (mean age 33 years), 24 were men. Three were obese, seven had hyperlipidemia and two had impaired glucose tolerance. Thirteen patients presented with pain in the right hypochondrium, three with fatigue and weakness, and nine were asymptomatic. No patient had evidence of portal hypertension or liver cell failure. Mild elevation of ALT was the most common biochemical abnormality. Twenty-three of the 25 patients had ALT/AST ratio >1.0. Liver histology revealed macrovesicular steatosis in all, with mild inflammatory activity in the majority (70%). Fibrosis was seen in 12 patients-portal fibrosis in six, periportal fibrosis in three and bridging fibrosis in another three patients. None of the patients had features of cirrhosis. None of the factors was found to be associated with fibrosis except serum AST level, which was significantly higher in patients with fibrosis as compared to those without (89 [52] vs. 54 [18] IU/L; p<0.05). CONCLUSIONS: NASH is often seen in men, in the absence of obesity, diabetes and hyperlipidemia, and its severity is better assessed by liver histology than clinical assessment.en_US
dc.description.affiliationDepartment of Gastroenterology, G B Pant Hospital, New Delhi.en_US
dc.identifier.citationAgarwal SR, Malhotra V, Sakhuja P, Sarin SK. Clinical, biochemical and histological profile of nonalcoholic steatohepatitis. Indian Journal of Gastroenterology. 2001 Sep-Oct; 20(5): 183-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64783
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBiopsyen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshFatty Liver --diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.titleClinical, biochemical and histological profile of nonalcoholic steatohepatitis.en_US
dc.typeJournal Articleen_US
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