Evaluation of aspartate amino transferase to platelet ratio index as a non invasive marker for liver cirrhosis

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dc.contributor.authorFeros, Mohammeden_US
dc.contributor.authorShanmugam, Lokeshen_US
dc.date.accessioned2020-04-09T07:41:23Z
dc.date.available2020-04-09T07:41:23Z
dc.date.issued2019-03
dc.description.abstractBackground: Cirrhosis is a condition in which the liver slowly deteriorates and is unable to function normally due to chronic long lasting injury. Liver biopsy is considered as a gold standard for the diagnosis of cirrhosis and has many problems like bleeding, infective peritonitis which limit use of liver biopsies in all patients.Methods: A comparative study was done (90 cases and 90 controls) who fulfilled the inclusion criteria in a tertiary center.Results: The present study was conducted using a total of 180 participants, 90 USG diagnosed cases of liver cirrhosis was compared with 90 healthy controls. The mean AST level in the cirrhosis was 66.50±27.06 as compared to 21.26±6.52 in controls which was statistically significant. In this study the sensitivity and specificity of APRI was found to be 100.0% and 84.44% respectively, and the positive and negative predictive values were 86.54% and 100% respectively with significantly Area under the curve (AUC) (0.999, P>0.01).Conclusions: A simple index like Aspartate platelet ratio index, consisting of 2 readily available laboratory results (AST level and platelet count), can predict cirrhosis with a high degree of accuracy.en_US
dc.identifier.affiliationsDepartment of General Medicine, Mahatma Gandhi Medical College and Research Institute, Puducherry, Indiaen_US
dc.identifier.citationFeros Mohammed, Shanmugam Lokesh. Evaluation of aspartate amino transferase to platelet ratio index as a non invasive marker for liver cirrhosis. International Journal of Advances in Medicine. 2019 Mar; 6(2): 216-221en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194201
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20191036en_US
dc.subjectAspartate platelet ratio indexen_US
dc.subjectAspartate amino transferaseen_US
dc.subjectComplete blood counten_US
dc.subjectCirrhosisen_US
dc.subjectLiver function testen_US
dc.subjectUltrasounden_US
dc.titleEvaluation of aspartate amino transferase to platelet ratio index as a non invasive marker for liver cirrhosisen_US
dc.typeJournal Articleen_US
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