Intracranial pressure changes with different doses of lignocaine under general anaesthesia.

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dc.contributor.authorGrover, V Ken_US
dc.contributor.authorReddy, G Men_US
dc.contributor.authorKak, V Ken_US
dc.contributor.authorSingh, Sen_US
dc.date.accessioned1999-06-13en_US
dc.date.accessioned2009-06-03T10:23:13Z
dc.date.available1999-06-13en_US
dc.date.available2009-06-03T10:23:13Z
dc.date.issued1999-06-13en_US
dc.description.abstractThe effect of intravenous lignocaine on intracranial pressure (ICP) was studied on thirty patients of either sex, aged above 5 years and scheduled for elective ventriculoperitoneal shunt surgery. The patients were randomly divided into 3 groups, which received intravenous lignocaine in the dose of 1 mg, 1.5 mg and 2 mg/kg body weight respectively. Intracranial pressure, heart rate, ECG, arterial pressure and arterial blood gases were monitored at various intervals for a period of 30 minutes. Maximum decrease in ICP was seen at 2 minutes after IV lignocaine in all the three groups (p<0. 001). The fall in ICP was significantly more in group II and group III (35.65% and 37.5% respectively) as compared to group I (17.47%) (p<0.001). This fall in ICP in all the three groups persisted below the basal level, throughout the study period. None of the groups showed any significant change in the heart rate, but a statistically significant fall in arterial pressure was observed in group III (p<0. 05). In conclusion intravenous lignocaine, in a dose of 1.5 mg/kg, causes significant fall in ICP without causing any untoward cardiovascular effects and is recommended for routine clinical use.en_US
dc.description.affiliationDepartments of Anaesthesia and Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.en_US
dc.identifier.citationGrover VK, Reddy GM, Kak VK, Singh S. Intracranial pressure changes with different doses of lignocaine under general anaesthesia. Neurology India. 1999 Jun; 47(2): 118-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/120189
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAnesthesia, Generalen_US
dc.subject.meshAnesthetics, Localen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntracranial Pressureen_US
dc.subject.meshLidocaineen_US
dc.subject.meshMaleen_US
dc.titleIntracranial pressure changes with different doses of lignocaine under general anaesthesia.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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