Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in diabetic foot infections.

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dc.contributor.authorVaraiya, Ami Yen_US
dc.contributor.authorDogra, Jyotsana Den_US
dc.contributor.authorKulkarni, Manasi Hen_US
dc.contributor.authorBhalekar, Pallavi Nen_US
dc.date.accessioned2008-07-30en_US
dc.date.accessioned2009-05-29T12:15:30Z
dc.date.available2008-07-30en_US
dc.date.available2009-05-29T12:15:30Z
dc.date.issued2008-07-30en_US
dc.description.abstractAIMS: Diabetic foot lesions are a major medical, social, and economic problem and are the leading cause of hospitalization for patients with diabetes, worldwide. ESBL-producing bacteria may not be detectable by routine disc diffusion susceptibility test, leading to inappropriate use of antibiotics and treatment failure. There is not much information on ESBL-producing organisms causing diabetic foot infection. An attempt was therefore made to study the ESBL-producing Escherichia coli and Klebsiella pneumoniae in diabetic foot patients with type 2 diabetes mellitus. MATERIALS AND METHODS: A total of 134 isolates of E. coli and K. pneumoniae were obtained from tissue, pus swab, and wound swab samples from diabetic foot ulcers submitted for routine microbiological analysis during the period January to December 2005 from patients with diabetic foot infections who had type 2 diabetes mellitus, attending S. L. Raheja Hospital. The above isolates were tested for antimicrobial susceptibility by disc diffusion technique according to clinical and laboratory standards institute (CLSI) guidelines. The screening for ESBL production was done by phenotypic confirmatory test using ceftazidime disc in the presence and absence of clavulanic acid as recommended by CLSI. RESULTS: Among the 134 isolates, 54 (40.29%) were E. coli and 80 (59.70%) were K. pneumoniae; among which, ESBL production was detected in 31 (23.13%) isolates. Of these 31, 15 (48.38%) were E. coli and 16 (51.61%) were K. pneumoniae. All the ESBL-producing isolates were found to be 100% sensitive to carbapenem (imipenem and meropenem). Mortality was found to be 3.22%, the cause of death being septicemia leading to multiple organ failure. CONCLUSIONS: The prevalence of ESBLs among members of Enterobacteriaceae constitutes a serious threat to the current beta-lactam therapy, leading to treatment failure and consequent escalation of costs. There is an urgent need to emphasize rational use of drugs to minimize the misuse of available antimicrobials.en_US
dc.description.affiliationDepartment of Microbiology, S. L. Raheja Hospital, Mumbai, India. amivaraiya@yahoo.comen_US
dc.identifier.citationVaraiya AY, Dogra JD, Kulkarni MH, Bhalekar PN. Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in diabetic foot infections. Indian Journal of Pathology & Microbiology. 2008 Jul-Sep; 51(3): 370-2en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/74398
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshDiabetes Mellitus, Type 2 --complicationsen_US
dc.subject.meshDiabetic Foot --complicationsen_US
dc.subject.meshEscherichia coli --enzymologyen_US
dc.subject.meshEscherichia coli Infections --microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKlebsiella Infections --microbiologyen_US
dc.subject.meshKlebsiella pneumoniae --enzymologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshSepsis --etiologyen_US
dc.subject.meshbeta-Lactamases --biosynthesisen_US
dc.subject.meshbeta-Lactams --pharmacologyen_US
dc.titleExtended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in diabetic foot infections.en_US
dc.typeJournal Articleen_US
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