Acantholysis revisited: Back to basics.
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Date
2013-01
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Abstract
Acantholysis means loss of coherence between epidermal cells due to the breakdown of intercellular bridges. It is an important pathogenetic mechanism underlying various bullous disorders, particularly the pemphigus group, as well as many non-blistering disorders. Although a well-known concept, the student often has to refer to many sources to comprehend acantholysis completely. Thorough knowledge of this topic helps in clinching many diagnoses. The etiopathogenesis, classification, clinical signs, and laboratory demonstration of acantholysis are discussed in detail to help students build clear concepts. We have focused on various distinguishing points in different disorders for an easy grasp of the topic.
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Keywords
Acantholysis, Nikolsky′s sign, primary, secondary
Citation
Seshadri Divya, Kumaran M Sendhil, Kanwar Amrinder J. Acantholysis revisited: Back to basics. Indian Journal of Dermatology, Venereology and Leprology. 2013 Jan-Feb; 79(1): 120-126.