Critical histopathological analysis of 25 dedifferentiated liposarcomas, including uncommon variants, reviewed at a Tertiary Cancer Referral Center.

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dc.contributor.authorRekhi, Bharat
dc.contributor.authorNavale, Pooja
dc.contributor.authorJambhekar, N A
dc.date.accessioned2012-10-18T04:20:01Z
dc.date.available2012-10-18T04:20:01Z
dc.date.issued2012-07
dc.description.abstractBackground: De-differentiated liposarcomas (DDLSs) are uncommon tumors with a wide histopathological spectrum. Materials and Methods: Over an 8-year period (2003-2011), 25 DDLSs, after review, were critically analyzed for histopathological features. Results: Twenty-five tumors, in 14 men and 11 women (M: F = 1.2:1), with age range of 22-88 years (mean, 53.9), occurred in retroperitoneum (14) (56%), thigh (3) (12%), paratesticular region (3) (12%), chest wall (2) (8%), leg (1) (4%), shoulder (1) (4%), and groin (1) (4%). Tumor size (21 tumors) varied from 7.5 to 25 cm (mean, 17.5). Histopathologically, DD component was high grade in 19 (76%) and low grade in 6 (24%) tumors. Whereas the most common WD component was adipocytic type; the most common DD component was pleomorphic sarcomatous (13) (52%), followed by myxofibrosarcomatous (MFS)-type (6) (24%). Low-grade DD components included MFS (2), fibrosarcoma (2), myogenic/myofibroblastic type (1), and IMFT-type (1). Three tumors displayed meningothelial-like whorls and metaplastic bone formation. Heterologous elements, noted in 11 (44%) tumors, included bone (8) and rhabdomyoblastic differentiation (2). Two tumors displayed homologous differentiation, reinforced with MDM2 staining. S100-P was diffusely positive in WD components (5/7) and focally in DD components (2/9). All patients were treated with surgery, including 10, who underwent adjuvant radiotherapy. Outcomes (16 patients, 64%), over 1-48 months included 10 patients free of disease, 4 died of disease, and 2 patients alive with disease. Conclusions: This study forms the largest documentation of DDLSs, including its wide histopathological spectrum, from our country. Rare cases overlap with pleomorphic liposarcoma. S100-P and MDM2 are useful in substantiating adipocytic differentiation, especially in selected cases. Analysis of adequate tumor sections is vital for correct identification of a DDLS. Surgical excision with adjuvant RT forms optimal treatment.en_US
dc.identifier.citationRekhi Bharat, Navale Pooja, Jambhekar N A. Critical histopathological analysis of 25 dedifferentiated liposarcomas, including uncommon variants, reviewed at a Tertiary Cancer Referral Center. Indian Journal of Pathology & Microbiology. 2012 Jul-Sept 55(3): 294-302.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142256
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=3;spage=294;epage=302;aulast=Rekhien_US
dc.subjectDedifferentiated liposarcomaen_US
dc.subjectliposarcomaen_US
dc.subjectMDM2en_US
dc.subjectmyxofibrosarcomaen_US
dc.subjectsoft tissue tumorsen_US
dc.subjectwell differentiated liposarcomaen_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshDiagnosis, Differential
dc.subject.meshFemale
dc.subject.meshHistocytochemistry
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshIndia
dc.subject.meshLiposarcoma --diagnosis
dc.subject.meshLiposarcoma --pathology
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshProto-Oncogene Proteins c-mdm2 --analysis
dc.subject.meshS100 Proteins --analysis
dc.subject.meshTertiary Care Centers
dc.titleCritical histopathological analysis of 25 dedifferentiated liposarcomas, including uncommon variants, reviewed at a Tertiary Cancer Referral Center.en_US
dc.typeArticleen_US
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