Critical histopathological analysis of 25 dedifferentiated liposarcomas, including uncommon variants, reviewed at a Tertiary Cancer Referral Center.
dc.contributor.author | Rekhi, Bharat | |
dc.contributor.author | Navale, Pooja | |
dc.contributor.author | Jambhekar, N A | |
dc.date.accessioned | 2012-10-18T04:20:01Z | |
dc.date.available | 2012-10-18T04:20:01Z | |
dc.date.issued | 2012-07 | |
dc.description.abstract | Background: De-differentiated liposarcomas (DDLSs) are uncommon tumors with a wide histopathological spectrum. Materials and Methods: Over an 8-year period (2003-2011), 25 DDLSs, after review, were critically analyzed for histopathological features. Results: Twenty-five tumors, in 14 men and 11 women (M: F = 1.2:1), with age range of 22-88 years (mean, 53.9), occurred in retroperitoneum (14) (56%), thigh (3) (12%), paratesticular region (3) (12%), chest wall (2) (8%), leg (1) (4%), shoulder (1) (4%), and groin (1) (4%). Tumor size (21 tumors) varied from 7.5 to 25 cm (mean, 17.5). Histopathologically, DD component was high grade in 19 (76%) and low grade in 6 (24%) tumors. Whereas the most common WD component was adipocytic type; the most common DD component was pleomorphic sarcomatous (13) (52%), followed by myxofibrosarcomatous (MFS)-type (6) (24%). Low-grade DD components included MFS (2), fibrosarcoma (2), myogenic/myofibroblastic type (1), and IMFT-type (1). Three tumors displayed meningothelial-like whorls and metaplastic bone formation. Heterologous elements, noted in 11 (44%) tumors, included bone (8) and rhabdomyoblastic differentiation (2). Two tumors displayed homologous differentiation, reinforced with MDM2 staining. S100-P was diffusely positive in WD components (5/7) and focally in DD components (2/9). All patients were treated with surgery, including 10, who underwent adjuvant radiotherapy. Outcomes (16 patients, 64%), over 1-48 months included 10 patients free of disease, 4 died of disease, and 2 patients alive with disease. Conclusions: This study forms the largest documentation of DDLSs, including its wide histopathological spectrum, from our country. Rare cases overlap with pleomorphic liposarcoma. S100-P and MDM2 are useful in substantiating adipocytic differentiation, especially in selected cases. Analysis of adequate tumor sections is vital for correct identification of a DDLS. Surgical excision with adjuvant RT forms optimal treatment. | en_US |
dc.identifier.citation | Rekhi Bharat, Navale Pooja, Jambhekar N A. Critical histopathological analysis of 25 dedifferentiated liposarcomas, including uncommon variants, reviewed at a Tertiary Cancer Referral Center. Indian Journal of Pathology & Microbiology. 2012 Jul-Sept 55(3): 294-302. | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/142256 | |
dc.language.iso | en | en_US |
dc.source.uri | https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=3;spage=294;epage=302;aulast=Rekhi | en_US |
dc.subject | Dedifferentiated liposarcoma | en_US |
dc.subject | liposarcoma | en_US |
dc.subject | MDM2 | en_US |
dc.subject | myxofibrosarcoma | en_US |
dc.subject | soft tissue tumors | en_US |
dc.subject | well differentiated liposarcoma | en_US |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Aged, 80 and over | |
dc.subject.mesh | Diagnosis, Differential | |
dc.subject.mesh | Female | |
dc.subject.mesh | Histocytochemistry | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Immunohistochemistry | |
dc.subject.mesh | India | |
dc.subject.mesh | Liposarcoma --diagnosis | |
dc.subject.mesh | Liposarcoma --pathology | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Proto-Oncogene Proteins c-mdm2 --analysis | |
dc.subject.mesh | S100 Proteins --analysis | |
dc.subject.mesh | Tertiary Care Centers | |
dc.title | Critical histopathological analysis of 25 dedifferentiated liposarcomas, including uncommon variants, reviewed at a Tertiary Cancer Referral Center. | en_US |
dc.type | Article | en_US |