Prevalence of BRCA1 expression in epithelial ovarian cancer: immunohistochemical study.

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dc.contributor.authorSirisabya, Nakarinen_US
dc.contributor.authorManchana, Tarineeen_US
dc.contributor.authorTermrungreunglert, Wichaien_US
dc.contributor.authorTriratanachat, Surangen_US
dc.contributor.authorCharuruks, Navapunen_US
dc.contributor.authorTresukosol, Damrongen_US
dc.date.accessioned2009-05-27T18:20:46Z
dc.date.available2009-05-27T18:20:46Z
dc.date.issued2007-01-12en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractThe 99 formalin fxed paraffin-embedded ovarian tissue specimens of Epithelial Ovarian Cancer (EOC) patients treated at the Gynecologic Oncology Unit, King Chulalongkorn Memorial Hospital between January 1, 1996 and December 31, 1999, were immuno-stained with BRCA antibody using the immunohistochemical method. According to the criteria for BRCA1 immunohistochemical evaluation (neoplastic nuclear staining more than 10%), 12 (12.1%) of the 99 specimens showed positive BRCA1 expression. No associated statistical significance between clinicopathological variables and BRCA expression was detected. Survival analysis was performed in 87 patients who were followed-up for more than 6 months and recent status were available. During a median follow-up of 43 months, median survival time was 46 months (range 6-84 months). No association between BRCA1 expression and survival outcomes was found (Disease free survival and overall survival) in the presented patients.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. drnakarin@hotmail.comen_US
dc.identifier.citationSirisabya N, Manchana T, Termrungreunglert W, Triratanachat S, Charuruks N, Tresukosol D. Prevalence of BRCA1 expression in epithelial ovarian cancer: immunohistochemical study. Journal of the Medical Association of Thailand. 2007 Jan; 90(1): 9-14en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38960
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshDisease-Free Survivalen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshGenes, BRCA1en_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOvarian Neoplasms --geneticsen_US
dc.subject.meshParaffin Embeddingen_US
dc.subject.meshSurvival Analysisen_US
dc.titlePrevalence of BRCA1 expression in epithelial ovarian cancer: immunohistochemical study.en_US
dc.typeJournal Articleen_US
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