Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians.
Loading...
Date
2009-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: To examine the possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection
against tuberculosis (TB) in Macedonians.
Method: 301 healthy unrelated individuals and 75 patients with pulmonary TB were studied. Cytokine genotyping was
performed by PCR with sequence-specific priming (PCR-SSP) (Heidelberg kit).
Results: TNF-Ü -238/G, IL-1R psti1970/C, IL-1â +3962/T:T, IL-4 -1098/ T:T, IFNã utr5644/A:A, IL-10 -1082/G:G, IL-
4 -590/C:C, IL-10/ATC, IL-4/TCT, IL-4/TCC, IL-10/ATC:GCC, IL-4/TCT:TTT, IL-4/TCC:TTC, IL-10/GCC:GCC and
IL-4/TCC:TCC were positively associated with TB, while protective association was identified for IL-4 -1098/G, IL-1â
+3962/C, IFNã utr5644/T, IL-1â +3962/C:T, IL-4 -1098/G:T, IL-4 -590/C:T, IFNã utr5644/A:T, IL-4/GCC, IL-4/TTC
and IL-4/GCC:TTC.
Conclusion: These results suggest that some cytokine polymorphisms are significantly associated and affect host
susceptibility/resistance to TB in Macedonians.
Description
Keywords
TB, Cytokine polymorphism, Macedonians
Citation
Trajkov Dejan, Trajchevska Mirjana, Arsov Todor, Petlichkovski Aleksandar, Strezova Ana, Efinska-Mladenovska Olivija, Sandevski Aleksandar, Spiroski Mirko. Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians. Indian Journal of Tuberculosis. 2009 Jul; 56(3): 117-131.