Exploring the Therapeutic Benefits of Saccharomyces boulardii CNCM I-745: A Potent Probiotic Solution

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dc.contributor.authorKumar, Aen_US
dc.contributor.authorKatkuri, DRen_US
dc.contributor.authorPrasad, GSen_US
dc.contributor.authorAhmed, Jen_US
dc.contributor.authorRao, KSSen_US
dc.contributor.authorReddy, BS.en_US
dc.date.accessioned2025-05-12T08:15:09Z
dc.date.available2025-05-12T08:15:09Z
dc.date.issued2024-08
dc.description.abstractHumans and microbes have a close symbiotic relationship, particularly in the gut, where more than 1000 species contribute to its development and maturation. The gut microbiota is essential for normal physiological development, as it supports the maturation and differentiation of the gut mucosa and its immune system. As an infant’s diet evolves, the microbiota becomes more complex, resembling that of an adult by early childhood. Malnutrition can disrupt this balance, leading to dysbiosis, which is characterized by a decrease in beneficial Bifidobacteria and an increase in harmful microbes such as Escherichia coli, Fusobacterium mortiferum, and Streptococcus spp. Dysbiosis is associated with a higher risk of various gastrointestinal diseases (GIDs), including inflammatory bowel disease, irritable bowel syndrome (IBS), and necrotizing enterocolitis. Probiotics play a crucial role in maintaining a balanced gut microbiota, making probiotic-based therapy a promising approach for preventing and treating GIDs. The mechanisms of action of probiotics include competitive adhesion and exclusion of potential pathogens, stimulation of intestinal epithelial cell proliferation, enhancement of the epithelial barrier, and interactions with the enteric nervous system and immune system. Yeasts offer several advantages as probiotics. They are stable in acidic and bile environments and can adhere to human intestinal cells. Saccharomyces boulardii CNCM I 745 is particularly effective in treating multiple gastrointestinal disorders, including traveller’s diarrhea, antibiotic-associated diarrhea (AAD), Clostridium difficile-associated syndrome, IBS, and Crohn’s disease. In addition, S. boulardii can survive the competitive environment of the intestinal tract and is naturally resistant to antibiotics and proteolysis, enhancing its effectiveness as a probiotic.en_US
dc.identifier.affiliationsDepartment of Pediatrician, Jaya Bhushan Hospital Pvt Ltd, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrician, Vatsalya Hospital, Jammikunta, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrician, Sai Prasad Children’s Hospital, Nizamabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrician, Niloufer Child Care Hospital, Nizamabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrician, Sai Ayush Children’s Hospital, Nizamabad, Telangana, Indiaen_US
dc.identifier.affiliationsDepartment of Paediatrician, Sunitha Children’s Hospital, Hyderabad, Telangana, Indiaen_US
dc.identifier.citationKumar A, Katkuri DR, Prasad GS, Ahmed J, Rao KSS, Reddy BS. . Exploring the Therapeutic Benefits of Saccharomyces boulardii CNCM I-745: A Potent Probiotic Solution. International Journal of Scientific Study. 2024 Aug; 12(5): 28-37en_US
dc.identifier.issn2321-6379
dc.identifier.issn2321-595X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246968
dc.languageenen_US
dc.publisherInternational Research Organization for Life & Health Sciencesen_US
dc.relation.issuenumber5en_US
dc.relation.volume12en_US
dc.source.urihttps://www.ijss-sn.com/uploads/2/0/1/5/20153321/ijss_aug_24_ra03_-_2024.pdfen_US
dc.subjectAcute diarrheaen_US
dc.subjectDysbiosisen_US
dc.subjectGut microbiotaen_US
dc.subjectProbioticen_US
dc.subjectSaccharomyces boulardiien_US
dc.titleExploring the Therapeutic Benefits of Saccharomyces boulardii CNCM I-745: A Potent Probiotic Solutionen_US
dc.typeJournal Articleen_US
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