A pilot trial for comparison of photodynamic therapy and transpupillary thermotherapy for the management of classic subfoveal choroidal neovascularization secondary to age-related macular degeneration.

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dc.contributor.authorTewari, Hem Ken_US
dc.contributor.authorPrakash, Gauraven_US
dc.contributor.authorAzad, Raj Ven_US
dc.contributor.authorTalwar, Dineshen_US
dc.contributor.authorKai, Sanjayen_US
dc.date.accessioned2007-07-28en_US
dc.date.accessioned2009-05-29T07:51:04Z
dc.date.available2007-07-28en_US
dc.date.available2009-05-29T07:51:04Z
dc.date.issued2007-07-28en_US
dc.description.abstractAIM: The aim of the study was to compare the visual outcomes of photodynamic therapy (PDT) with verteporfin and transpupillary thermotherapy (TTT) for classic subfoveal choroidal neovascularization (CNVM) secondary to age-related macular degeneration (ARMD). SETTINGS AND DESIGN: Patients with subfoveal classic CNVM caused by ARMD attending vitreo-retinal services at a tertiary care setup were included in this nonrandomized, open label, prospective, clinical, comparative pilot trial. MATERIALS AND METHODS: Standardized refraction, visual acuity testing, evaluation of fundus and serial color photography and fundus fluorescein angiography were carried out to evaluate the effects of treatment in 32 eyes each undergoing either PDT or TTT. Follow-up was carried out at four weeks, 12 weeks and six months. Retreatment if indicated was carried out three months post treatment. RESULTS: Stabilization or improvement occurred in 69% of patients undergoing PDT and 50% patients undergoing TTT at six months of follow-up. Among patients with a pretreatment visual acuity greater than or equal to 20/63, only one out of six patients who underwent PDT had a drop of visual acuity > 2 lines as compared to four patients (100%) who underwent TTT. (P =0.0476, two-tailed Fisher's exact test). CONCLUSION: For short-term preservation of vision in patients of classic CNVM due to ARMD, PDT seems to be better than TTT if the pre-laser best corrected visual acuity is > 20/63 but both are equally effective if pre-laser best corrected visual acuity is < 20/63.en_US
dc.description.affiliationCentre for Sight, Safdarjang Enclave, New Delhi, India.en_US
dc.identifier.citationTewari HK, Prakash G, Azad RV, Talwar D, Kai S. A pilot trial for comparison of photodynamic therapy and transpupillary thermotherapy for the management of classic subfoveal choroidal neovascularization secondary to age-related macular degeneration. Indian Journal of Ophthalmology. 2007 Jul-Aug; 55(4): 277-81en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/69812
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshAgeden_US
dc.subject.meshChoroidal Neovascularization --diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescein Angiographyen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshFundus Oculien_US
dc.subject.meshHumansen_US
dc.subject.meshHyperthermia, Induced --methodsen_US
dc.subject.meshMacular Degeneration --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhotochemotherapy --methodsen_US
dc.subject.meshPhotosensitizing Agents --therapeutic useen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPorphyrins --therapeutic useen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVisual Acuityen_US
dc.titleA pilot trial for comparison of photodynamic therapy and transpupillary thermotherapy for the management of classic subfoveal choroidal neovascularization secondary to age-related macular degeneration.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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