Phenolic compounds in grapes (genus Vitis): A review of their antioxidant activity, antiproliferative capacity, and cytotoxic effect on colorectal cancer

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dc.contributor.authorNeira-Ospina, Een_US
dc.contributor.authorRojas, Jen_US
dc.contributor.authorSanta-Gonzalez, GAen_US
dc.contributor.authorGarzón, MAGen_US
dc.date.accessioned2024-11-30T11:21:17Z
dc.date.available2024-11-30T11:21:17Z
dc.date.issued2024-06
dc.description.abstractIn the pursuit of potent antioxidant sources for potential health benefits, significant attention has been directed toward polyphenols. This research is especially relevant in the context of colorectal cancer (CRC), a widespread and deadly malignancy. The exploration of preventive strategies has led to a growing interest in grapes and their derivatives, such as juices and wines, which offer various consumption options based on grape type. This investigation encompasses a comprehensive analysis of multiple grape components: skin, pulp, seed, pomace, wine, juice, and extracts. These assessments serve as a critical reference for exploring functional ingredients from grapes and their potential as chemopreventive agents against colon cancer. This scientific literature review aims to provide an in-depth overview of advancements from 2012 to 2023. A systematic review reveals varying polyphenol concentrations in different grape components and their correlation with antioxidant capacities. In addition, the chemical profiles of these matrices are analyzed concerning their antioxidant properties, antiproliferative effects, and cytotoxicity, validated through in vitro and in vivo models simulating CRC scenarios. This research seeks to demonstrate grapes’ potential, in their diverse forms, as promising functional food options.en_US
dc.identifier.affiliationsGrupo de Investigación e Innovación Biomédica, Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnológico Metropolitano, Medellín, Colombiaen_US
dc.identifier.affiliationsDidáctica y Modelamiento en Ciencias Exactas y Aplicadas (DAVINCI), Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnológico Metropolitano, Medellín, Colombiaen_US
dc.identifier.affiliationsGrupo de Investigación e Innovación Biomédica, Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnológico Metropolitano, Medellín, Colombiaen_US
dc.identifier.affiliationsQuímica Básica, Aplicada y Ambiente Alquimia, Facultad de Ciencias Exactas y Aplicadas, Instituto Tecnológico Metropolitano, Medellín, Colombia.en_US
dc.identifier.citationNeira-Ospina E, Rojas J, Santa-Gonzalez GA, Garzón MAG. Phenolic compounds in grapes (genus Vitis): A review of their antioxidant activity, antiproliferative capacity, and cytotoxic effect on colorectal cancer. Journal of Applied Pharmaceutical Science. 2024 Jun; 14(6): 71-89en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237668
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber6en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.7324/JAPS.2024.169381en_US
dc.subjectVitisen_US
dc.subjectfunctional fooden_US
dc.subjectantioxidant capacityen_US
dc.subjectcolorectal canceren_US
dc.subjectchemoprevention.en_US
dc.titlePhenolic compounds in grapes (genus Vitis): A review of their antioxidant activity, antiproliferative capacity, and cytotoxic effect on colorectal canceren_US
dc.typeJournal Articleen_US
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